Dexmedetomidine Added to Bupivacaine Versus Bupivacaine inTransincisionalU/S Guided Quadratus Lumborum Block in Open Renal Surgeries , A New Technique

Phase 4

Completed

• Conditions: Anesthesia
• Interventions: Drug: Dexmedetomidine +bupivacaine; Drug: Bupivacaine

• Registration Number: NCT03869047
• Lead Sponsor: Ain Shams University

Brief Summary

The purpose of this study is to compare the addition of dexmedetomidine to bupivacaine versus bupivacaine only in anterior QLblock(transincisional) , where the local anesthetic will be applied before wound closure at the end of surgery through the wound . in combination with general anesthesia in elective open renal surgery with regard to Postoperative pain control,hemodynamic stability, and adverse effects.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-03-06
• Study First Submitted: 2019-03-06
• Study First Submitted QC: 2019-03-08
• Study First Posted: 2019-03-11
• Primary Completion: 2019-08-01
• Study Completion: 2019-08-15
• Status Verified: 2020-05
• Last Update Submitted: 2020-05-18
• Last Update Posted: 2020-05-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• physical status American Society of Anesthesiologist (ASA) I or II

Exclusion Criteria

• Patients refusal
• A body mass index (BMI) >30 kg/m2
• ASA physical status >II
• major illnesses (e.g., cardiac, respiratory, renal, hepatic or neurological)
• Coagulation abnormalities
• Infection at the injection site
• Allergy or contraindications to the drugs used in the study
• History of drug addiction or alcohol abuse
• A psychiatric illness, or mental retardation interfering with the evaluation of pain scores or PCA programs .

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
quadratus lumborum block(dexmedetomidine+bupivacaine)	Dexmedetomidine +bupivacaine	patients will receive combined general anesthesia and Quadratuslumborum block( transincisional ie before wound closure)with 19 mL of bupivacaine 0.20%plus 1 mic/kg of dexmedetomidine ,total volume 20 ml.
quadratus lumborum block(bupivacaine)	Bupivacaine	patients will receive combined general anesthesia and quadratus lumborum block (transincisional) with 20 ml of bupivacaine 0.20%.

Primary Outcome Measures

Name	Time	Method
First time to analgesic requirement	1st 24 hour postoperatively	After extubation, an intravenous patient - controlled system, will be connected to the patient (Accufuser plus 100 ml) will be prepared with 60 ml isotonic saline containing 60 mg morphine , it will be programmed to give 0.5 ml bolus dose with lockout interval of 8 minutes. Time to first bolus will be recorded considering extubation time is the zero time

Secondary Outcome Measures

Name	Time	Method
the secondary outcomes will be the total opioid consumption postoperatively	1st 24 hour	PCA will prepared with 60 mL of normal saline containing 60 mg of morphine, and the system will be programmed to give a 0.5 mL bolus dose with a lockout interval of 8 min.

Trial Locations

Locations (1)

Ain Shams University hospitals; 🇪🇬 Cairo, Egypt