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临床试验/NCT05479786
NCT05479786已完成不适用

Evaluation of Reproductive Outcomes After Expectant or Surgical Management of a Previous Episode of Tubal Ectopic Pregnancy

University of Palermo0 个研究点目标入组 312 人开始时间: 2012年1月1日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
312
主要终点
Clinical pregnancy rate

研究概览

简要总结

Although ectopic pregnancy was considered a leading cause of first-trimester maternal mortalities, current technological improvements allowed early diagnosis and opened a door for applying less invasive approaches. A tubal pregnancy could be managed either expectantly, medically, or surgically. The expectant management of ectopic pregnancy relies on the fact that a considerable proportion of ectopic gestations terminate by spontaneous tubal abortion. This approach is usually kept for stable cases with a small gestational sac and low beta-human chorionic gonadotropin (beta-HCG) serum levels. For hemodynamically unstable patients, higher levels of beta-HCG, and larger gestational sacs, surgery is often considered as the treatment of choice (16).

Considering this background, the study aims to analyze the subsequent natural reproductive outcomes of patients that had a previous tubal ectopic pregnancy and were managed either expectantly or surgically. Moreover, it amis to determine the factors that could influence the fertility potential of these patients in each treatment group.

研究设计

研究类型
Observational
观察模型
Case Control
时间视角
Retrospective

入排标准

年龄范围
18 Years 至 45 Years(Adult)
性别
Female
接受健康志愿者

入选标准

  • Women with one episode of tubal ectopic pregnancy, treated by expectant management, salpingectomy, or salpingostomy;
  • For patients treated surgically, only patients with at least one patent Fallopian tube confirmed via postoperative hysterosalpingography were included in the analysis.

排除标准

  • Pregnancies of unknown location
  • Other types of ectopic pregnancy
  • Pelvic inflammatory disease
  • Pelvic adhesions
  • Intrauterine pathologies
  • Pregnancies obtained after assisted-reproductive technologies (ART)

结局指标

主要结局

Clinical pregnancy rate

时间窗: Within one year after the previous episode of tubal ectopic pregnancy

Presence of a gestational sac under ultrasonography

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Antonio Simone Laganà

Principal Investigator

University of Palermo

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