Novel Type 2 Diabetes Mellitus Preventive Therapies

Boston Medical Center1 site in 1 country12 target enrollmentMay 2010

ConditionsDiabetes

InterventionsGlutamine (Pharmacological doses)Lifestyle change

DrugsGlutamine (Pharmacological doses)

Overview

Phase: Phase 1
Intervention: Glutamine (Pharmacological doses)
Conditions: Diabetes
Sponsor: Boston Medical Center
Enrollment: 12
Locations: 1
Primary Endpoint: Weight gain
Status: Completed
Last Updated: 11 years ago

Overview Investigators Eligibility Criteria Arms & Interventions Outcomes Sites Similar Trials

Overview

Brief Summary

Over the past two decades, type 2 diabetes mellitus (T2DM) has emerged from relative obscurity to become one of the most serious complications of obesity in Hispanic obese populations, especially among those with a family history of T2DM. Few therapies have demonstrated long term efficacy in combating obesity and risk of T2DM in youth. Given the emerging evidence that glutamine and leucine (building blocks of protein) may affect energy partition and thus diabetes risk, and that the relationship of glutamine and diabetic risk has been further evaluated in one adult observational cohort study but data on leucine are lacking, we plan to conduct a clinical trial to determine the efficacy of glutamine to reduce insulin resistance, a diabetes risk factor.

The primary specific aim of the research plan is to conduct a randomized, double-blind, placebo controlled, clinical trial to test the efficacy of 6 months supplements of glutamine in reducing biomarkers for insulin resistance and weight gain among 56 obese Hispanic adolescents age 12-19 years with a BMI at or above the 95th percentile and a family history of T2DM. At the end of the grant period, we will have obtained preliminary data to plan pivotal clinical trials of glutamine coupled with or without lifestyle changes.

Detailed Description

Because of recruitment difficulties the design was modified several times until April 2013 when we were able to increase recruitment. The following changes were made from initial to final study design: 1. Study moved from Clinical and Translational Science Institute (CTSI) to clinical setting (Nutrition and Fitness for Life Clinic) 2. Ages eligible expanded from 12-19 years old to 12-19.9 years old 3. Ethnicity/Race expanded from Hispanic only to include all races/ethnicities 4. Patients without a past family history of T2DM were made eligible 5. Study period was shortened from 6 months to 12-14 weeks 6. Number of required visits were reduced from 5 visits to 3 visits (all of which took place during regularly scheduled clinic appointments) 7. Open labeled but still randomized 8. Those in the Glutamine arm were provided lifestyles change intervention 9. Glycosylated hemoglobin (A1C) used instead of fasting Homeostatic Model Assessment-Insulin Resistance (HOMA-IR) 10. Non-fasting blood draw rather than a fasting blood draw was instituted

Registry

clinicaltrials.gov

Start Date

May 2010

End Date

August 2014

Last Updated

11 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

Boston Medical Center

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•BMI (k/m2) \>= 95th percentile;
•Weight 150 - 400 pounds;
•Language: English or Spanish (The PI speaks both English and Spanish fluently).

Exclusion Criteria

•History of T2DM;
•Prior or current drug treatmeant that would effect diabetes risk
•Use of prescription strength glucocorticoids within three months before screening,
•History of syndrome or medical disorder associated with significant obesity;
•Serum creatinine \>1.2 mg/dL;
•Alanine transaminase (ALT) or Aspartate aminotransferase (AST) \>90 international units (IU)/L (= 3 X normal limits);
•Total bilirubin \>2.5 time the upper limit of normal;
•History of moderate to extreme physical activity, past or current pregnancy;
•9 .Use of illegal/illicit drugs;
•Unable to comply with the protocol;