Impact of tDCS on Cerebral Autoregulation

Not Applicable

Completed

• Conditions: Cerebral Microangiopathy; Migraine With Aura; ICA Stenosis; CADASIL
• Interventions: Device: Cathodal tDCS; Device: Anodal tDCS; Device: sham tDCS

• Registration Number: NCT01865604
• Lead Sponsor: Charite University, Berlin, Germany

Brief Summary

The aim of the study is to investigate whether there is a polarity-specific influence of tDCS on cerebral vasomotor reactivity monitored by transcranial doppler sonography.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-04
• Study First Submitted: 2012-12-18
• Study First Submitted QC: 2013-05-28
• Study First Posted: 2013-05-31
• Primary Completion: 2014-03
• Study Completion: 2014-03
• Status Verified: 2016-03
• Last Update Submitted: 2016-03-15
• Last Update Posted: 2016-03-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

1. severe cerebral Microangiopathy
2. NOTCH3 carrier
3. Migraine with aura (IHS Classification ICHD-II)
4. Stenosis >80%, ECST-Criteria

Exclusion Criteria

• seizure disorder
• history of severe alcohol or drug abuse, psychiatric illness like severe depression, poor motivational capacity
• dementia

(1+2) history of stroke in past 3 months (3) migraine prophylaxis (4) contralateral stenosis >50%,

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Cathodal tDCS	Cathodal tDCS	cathodal transcranial direct current stimulation
Anodal tDCS	Anodal tDCS	anaodal transcranial direct current stimulation
Sham tDCS	sham tDCS	no stimulation

Primary Outcome Measures

Name	Time	Method
Cerebral vasomotor reactivity assessed by transcranial Dopplersonography	on 3 days within 12 weeks	comparing cerebral vasomotor reactivity at baseline and after anodal/cathodal/sham stimulation

Trial Locations

Locations (1)

Department of Neurology, Charité Universitätsmedizin Berlin; 🇩🇪 Berlin, Germany