EUCTR2017-004669-28-ES
Active, not recruiting
Phase 1
A clinical tryal of the utility of ozone in patients with implantation failures
CENTRO GINECOLOGICO GINFER0 sites45 target enrollmentOctober 25, 2018
ConditionsEvaluate the action of ozone in the regulation, concentration and activation of uterine NK. Quantify the cytokines present in the uterine decidua pre and post ozone exposure in the uterus. Quantify the NK present in the uterine decidua pre and post ozone exposure in the uterus.Therapeutic area: Diseases [C] - Female diseases of the urinary and reproductive systems and pregancy complications [C13]
Overview
- Phase
- Phase 1
- Intervention
- Not specified
- Conditions
- Evaluate the action of ozone in the regulation, concentration and activation of uterine NK. Quantify the cytokines present in the uterine decidua pre and post ozone exposure in the uterus. Quantify the NK present in the uterine decidua pre and post ozone exposure in the uterus.
- Sponsor
- CENTRO GINECOLOGICO GINFER
- Enrollment
- 45
- Status
- Active, not recruiting
- Last Updated
- 6 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients who come to the reproduction unit who have previously undergone at least one cycle of IVF with their own oocytes or with donation of oocytes without achieving NRV and will make a deferred transfer, either from their own vitrified embryos or from donated embryos.
- •Age between 18 and 40 years
- •BMI (Body Mass Index) \<18 or\> 32 kg / m2
- •Current serologies (performed less than 6 months in advance) with full analysis battery
- •Immunological analysis prior to treatment, quantification of NK in blood, IL\-12, IL\-15 and IL\-18
- •In the previous cycle / years, the patient suffered
- •Repeated implementation failures (at least two transfers or failed transferences)
- •Suspected uterine factor compromised
- •Repeated miscarriages (at least two abortions)
- •Biochemical pregnancies (at least two pregnancy tests between 10\-20 mUI / ml in blood)
Exclusion Criteria
- •genetic diseases
Outcomes
Primary Outcomes
Not specified
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