Epigenetic Signature of Advance Glycation End Products (AGE) and Skin Autofluorescence As a Risk Predictor in Metabolically Healthy and Unhealthy Obese Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 26
- 试验地点
- 1
- 主要终点
- Weight in kilograms, height in meter (will be combined to report BMI in kg/m^2)
研究概览
简要总结
The goal of this interventional study is to learn about the improvement in body composition effects of lifestyle intervention in subjects with metabolic syndrome. The main question it aims to answer is:
Does life style intervention lower body fat% and gene methylation levels in subjects with metabolic syndrome? Participants will answer survey questions and get blood and body composition testing done at day 0, and 12 months. Keep a diary of their food and activity and the number of times they use mobile health application.
详细描述
This is same as above.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Less than 5 kg body weight fluctuation in the 6 months prior to recruitment.
- •Ideal body weight for height falling according to the South Asian Criteria as per WHO recommended i.e. Body Mass Index (BMI) of 18.5 to 22.9 kg/m2 (normal-weight) and above 23kg/m2 (overweight/ obese).
- •Any one of the following characteristics "according to the modified National Cholesterol Education Program (NCEP) ATPIII guidelines i) waist circumference ii) hyper triglyceridemia (triglycerides ≥150 mg/dl) or low High density lipoprotein (HDL) cholesterol (HDL cholesterol ≤40 mg/dl for men and ≤50 mg/dl for women iii) elevated blood pressure (systolic blood pressure ≥130 mmHg and/or diastolic blood pressure ≥85 mmHg or current use of antihypertensive drugs) iv) impaired fasting glucose (fasting plasma glucose ≥100mg/dl) v) waist circumference (90 cm in men and 80 cm in women)".
- •Have access to a smart phone/mobile and not using the fitness application
排除标准
- •Age <18 or above 65 year
- •Pregnant women
- •Individuals with other comorbidities such as cancers, hepatic and/or renal impairment, or on hormonal supplements and/or anti-inflammatory drugs etc.
- •Unfit for blood testing or no smart phone available
研究组 & 干预措施
Lifestyle modification through m-health
Individuals recruited will be followed for a year and offered lifestyle intervention
干预措施: mobile health lifestyle intervention (Other)
结局指标
主要结局
Weight in kilograms, height in meter (will be combined to report BMI in kg/m^2)
时间窗: one year
A weighing scale will be used for this and values recorded on a questionnaire
Advance glycation end product (U/mL) from serum
时间窗: one year
This serum biomarker level will be assessed by Enzyme linked immunosorbent assay (ELISA) at the laboratory. Values will be recorded as Units per milliliter on a questionnaire.
Body fat percentage
时间窗: 1 year
Body composition will be measured by Bioelectrical impedance matching (BIA) and computerized topography (CT) scans. The reports will be shared with the participants and values will be recorded on a questionnaire.
次要结局
- Meal quality and calorie count(1 year)
- Methylation level of genes(1 year)
研究者
Sadia Fatima
Associate Professor
Aga Khan University