Multi-pronged Ethanol Ablation and Radiofrequency Ablation of Early-stage Hepatocellular Carcinoma
Not Applicable
Completed
- Conditions
- Hepatocellular Carcinoma
- Interventions
- Procedure: multi-pronged ethanol ablationProcedure: radiofrequency ablation
- Registration Number
- NCT00844454
- Lead Sponsor
- Sun Yat-sen University
- Brief Summary
The purpose of this study is to compare the effectiveness of percutaneous ethanol ablation using a multi-pronged needle (QFEA) with that of percutaneous radiofrequency ablation (RFA) in the treatment of early-stage hepatocellular carcinoma (HCC).
- Detailed Description
Patients with early-stage (single tumor no more than 5 cm or up to 3 tumors each no more than 3 cm in size) primary hepatocellular carcinoma will be randomized into two percutaneous ablation treatment arms, including radiofrequency ablation and multi-pronged ethanol ablation. The local treatment responses, complications,and long-term disease-free survivals and overall survivals are analyzed.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 81
Inclusion Criteria
- Primary hepatocellular carcinoma, single tumor ≤5 cm or up to 3 tumors each ≤3 cm
- Ultrasound detectable tumor
- Liver function classified as Child-Pugh A or B
- Platelet count > 50,000/mm3, or prothrombin activity > 50%
- Not suitable for resection or patient refused surgery
Exclusion Criteria
- Vascular invasion and extrahepatic spread
- Patients allergic to ethanol
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description QFEA multi-pronged ethanol ablation multi-pronged ethanol ablation RFA radiofrequency ablation radiofrequency ablation
- Primary Outcome Measures
Name Time Method Local treatment responses 2 years
- Secondary Outcome Measures
Name Time Method Disease-free survivals and overall survivals 3 years
Trial Locations
- Locations (1)
The First Affiliated Hospital of Sun Yat-Sen University
🇨🇳Guangzhou, Guangdong, China