Adaptation of Skills Training Manuals for Patients Receiving Hematopoietic Stem Cell Transplantation and Their Caregivers

Active, not recruiting

• Conditions: Post Hematopoietic Stem Cell Transplantation
• Interventions: Behavioral: semi-structured interviews

• Registration Number: NCT02928185
• Lead Sponsor: Memorial Sloan Kettering Cancer Center

Brief Summary

The purpose of this study is to see what the patients perceptions are of the Coping Together manuals during the first 100 days after their Hematopoietic Stem Cell Transplantation (HSCT), and if they would make any changes to Coping Together manuals for future patients, caregivers and couples that use these manuals after their HSCT. The investigators would also like to see what is the caregiver's perception of this intervention, and to see if they have any suggestions for changes. If the caregiver is interested in providing feedback, they will sign a separate consent form.

Detailed Description

A two-part, qualitative descriptive design will be employed to systematically adapt the Coping Together manuals based on recommendations of HSCT patients, CGs, dyads and clinicians (for Phase 1 only). For this study, CG is defined as spouse, partner, family member, friend, colleague, or neighbor who can, but do not necessarily live together, and provide uncompensated care. A dyad is defined as a combination of a patient and their designated CG. Dyads can review the Coping Together manuals individually or jointly, but will be interviewed together.

Part 1 will capture diverse perspectives of HSCT patients, CGs, dyads and clinicians using individual (patients, CGs, clinicians) and dyadic (dyads) interviews for the preliminary adaptation of the Coping Together manuals.

Part 2 will explore the experiences of HSCT patients, CGs and dyads with HSCT CT, which will be the HSCT-modified version of the Coping Together manuals, using individual (patients, CGs) and dyadic (dyads) interviews to refine the HSCT CT manuals.

Study Timeline

• Study Start: 2016-09
• Study First Submitted: 2016-10-06
• Study First Submitted QC: 2016-10-06
• Study First Posted: 2016-10-10
• Status Verified: 2024-08
• Last Update Submitted: 2024-08-19
• Last Update Posted: 2024-08-20
• Primary Completion: 2025-09
• Study Completion: 2025-09

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 41

Inclusion Criteria

Part 1

HSCT Patients

• Admission to the MSKCC Adult BMT service for an outpatient HSCT for a hematologic malignancy
• HSCT procedure scheduled within two months of consent
• ≥18 years old
• Ability to read, speak and understand English
• Able to give written informed consent
• Physically and cognitively able to participate in the study as determined by the investigators HSCT CGs
• ≥18 years old
• Ability to read, speak and understand English
• Able to give written informed consent
• Physically and cognitively able to participate in the study as determined by the investigators

HSCT Dyads

• In addition to meeting the inclusion criteria for HSCT Patients and HSCT CGs above, both parties must provide mutual agreement to participate as a dyad.

HSCT Clinicians

• Member of MSKCC BMT patient care team for at least one year

Part 2

HSCT Patients

• Same as Part 1 HSCT Patients HSCT CGs
• Same as Part 1 HSCT CGs HSCT Dyads
• Same as Part 1 HSCT Dyads

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Exclusion Criteria

Part 1 HSCT Patients

• Physically and cognitively unable to participate in the study as determined by the investigators HSCT CGs
• Inability to complete role responsibilities 24 hours per day for at least 50% of time (50 days)
• Physically and cognitively unable to participate in the study as determined by the investigators HSCT Dyads
• Participants must not meet the exclusion criteria for HSCT Patients and HSCT CGs above.
• Patients or CGs who are participating in this study as individuals HSCT Clinicians
• There are no exclusion criteria

Part 2 HSCT Patients

• Same as Part 1 HSCT Patients HSCT CGs
• Same as Part 1 HSCT CGs HSCT Dyads
• Same as Part 1 Dyads

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
HSCT care givers	semi-structured interviews	Individual/dyadic semi-structured interviews between Day +100 to +130
HSCT dyads	semi-structured interviews	Individual/dyadic semi-structured interviews between Day +100 to +130
HSCT patients	semi-structured interviews	Individual/dyadic semi-structured interviews between Day +100 to +130
HSCT Clinicians	semi-structured interviews	Can include: MD, RN, SW, PharmD and Nutritionist. Individual semi-structured interviews after 14 days to review the Coping Together manuals

Primary Outcome Measures

Name	Time	Method
finalize the preliminary adaptation of the manuals	1 year	Socio-demographic characteristics will be summarized with descriptive statistics (frequencies, percentages, means, standard deviations) using IBM SPSS® Statistics, Version 22.

Trial Locations

Locations (1)

Memorial Sloan Kettering Cancer Center; 🇺🇸 New York, New York, United States