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Clinical Trials/NCT07383376
NCT07383376
Completed
Not Applicable

Investigation of the Functional, Aesthetic, and Quality-of-life Effects of Combined Surgical-orthodontic Treatment

Semmelweis University1 site in 1 country50 target enrollmentStarted: January 6, 2025Last updated:
InterventionsSARMEMARPE

Overview

Phase
Not Applicable
Status
Completed
Enrollment
50
Locations
1
Primary Endpoint
Skeletal maxillary expansion measured with 3D scans

Overview

Brief Summary

This study aims to compare two different methods for maxillary expansion in adult patients with transverse maxillary deficiency. Participants will receive either miniscrew-assisted rapid palatal expansion (MARPE-MICRO-4). We want to compare the surgically assisted rapid palatal expansion (SARPE) and the non surgical/conservative method. Clinical (3D scans of the upper jaws) measurements will be used to evaluate skeletal expansion and stability over time. Approximately 40 adult patients will be included and followed for 12 months. The results of this study may help clinicians choose the most appropriate treatment method for adult maxillary expansion.

Study Design

Study Type
Interventional
Allocation
Non Randomized
Intervention Model
Parallel
Primary Purpose
Treatment
Masking
None

Eligibility Criteria

Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Presence of transverse maxillary deficiency requiring maxillary expansion
  • Indication for either non-surgical (MARPE) or surgically assisted (SARPE) maxillary expansion
  • Permanent dentition
  • Ability to understand the study procedures and provide informed consent

Exclusion Criteria

  • Previous maxillary expansion treatment
  • Craniofacial syndromes or cleft lip/palate
  • Severe periodontal disease
  • Active oral infection
  • Systemic conditions affecting bone metabolism
  • Pregnancy or breastfeeding
  • Inability to comply with study procedures or follow-up visits

Arms & Interventions

Surgically Assisted Rapid Maxillary Expansion

Active Comparator

Participants in this arm will undergo surgically assisted rapid palatal expansion (SARPE). The procedure will include surgical weakening of the maxillary sutures followed by maxillary expansion using a palatal expansion appliance. The appliance will be activated according to a standardized protocol. Clinical and radiographic assessments will be performed to evaluate treatment outcomes.

Intervention: SARME (Procedure)

Non-Surgically Assisted Rapid Maxillary Expansion

Experimental

Participants in this arm will undergo non-surgical maxillary expansion using a miniscrew-assisted rapid palatal expansion (MARPE) appliance. The appliance will be anchored to the palate using temporary anchorage devices (TADs) and activated according to a standardized expansion protocol. No surgical assistance will be performed in this group. Clinical and radiographic assessments will be used to evaluate treatment outcomes.

Intervention: MARPE (Device)

Outcomes

Primary Outcomes

Skeletal maxillary expansion measured with 3D scans

Time Frame: Baseline to 6 months after completion of maxillary expansion.

Changes in intermolar and intercanine width will be measured on digital dental models.

Secondary Outcomes

  • Buccal tipping of posterior teeth measured on 3D digital models(Baseline to 6 months after completion of maxillary expansion)

Investigators

Sponsor Class
Other
Responsible Party
Sponsor

Study Sites (1)

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