Impact of Stent Length and Diameter on Patients Undergoing Primary PCI

• Conditions: ST-segment Elevation Myocardial Infarction (STEMI)

• Registration Number: NCT04110691
• Lead Sponsor: Assiut University

Brief Summary

The goal of the study is to evaluate the Impact of coronary stent length and/or diameter in patients with ST segment myocardial infarction undergoing primary PCI, on Short term clinical outcomes.

Detailed Description

* ST segment elevation myocardial infarction is serious condition to the blood supply to the heart muscle. Rapid reperfusion of the ischemic myocardium using percutaneous coronary intervention (PCI) is the standard treatment for acute myocardial infarction (MI) to rescue the ischemic myocardium and reduce infarction size.

* There are two types of stents:

1. Drug-eluting stent which achieving local drug delivery to the injured blood vessel at the time of intervention, a drug is released from a polymer coating or loaded directly onto the stent (2). This is the best one.

2. Bare metal stent is the old one and not effective as DES in reducing vascular restenosis by suppressing smooth muscle cell (SMC) proliferation.

* The management of long coronary lesions by percutaneous coronary intervention (PCI) has become increasingly important because of the rising incidence of long or complex lesions in aging populations (3) Stent length has been considered as an important predictor of adverse events after PCI. The exact impact of lesion length on the short- and long-term clinical outcomes of DES implantations is not clear yet.

* Myocardial necrosis complicates one-third of percutaneous coronary intervention (PCI) and may adversely affect the outcome(4)

Study Timeline

• Study First Submitted: 2019-09-28
• Study First Submitted QC: 2019-09-28
• Study First Posted: 2019-10-01
• Status Verified: 2020-05
• Last Update Submitted: 2020-05-15
• Last Update Posted: 2020-05-19
• Study Start: 2020-07-01
• Primary Completion: 2021-09-30
• Study Completion: 2022-01-28

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• Patients with ST segment myocardial infarction who are eligible for PCI.
• All categories (all age groups and both sex groups)

Exclusion Criteria

• Patients with previous PCI.
• Patients of ectatic lesions.
• Patients with with multi vessel disease and suitable for CABG.
• Patients with complex lesions including bifurcational lesions and LM stenting.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
prognosis of patients with ST segment myocardial infarction undergoing primary PCI	3 months	prognosis will be measured with ECG and ECHO