Coronary and Peripheral Haemodynamic Studies of Angina with No Obstructive Coronary Artery Disease - association between invasive and non-invasive investigation modalities.
- Conditions
- AnginaCardiovascular - Coronary heart diseaseCardiovascular - Other cardiovascular diseases
- Registration Number
- ACTRN12618000178246
- Lead Sponsor
- niversity of Adelaide
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 60
1. Clinical diagnosis of angina
2. Persistent angina
3. Coronary angiography demonstrating normal or no obstructive coronary disease (<50% diameter stenosis)
1. Admission for an acute coronary syndrome within the preceding month
2. Prior coronary artery bypass grafting
3. Contra-indications to coronary haemodynamic assessment - patients with permanent pacemaker or defibrillator, severe renal or hepatic insufficiency, severe asthma, left ventricular systolic dysfunction (ejection fraction <50%)
4. Alternative coronary explanations for the chest pain - obstructive coronary artery disease (flow limiting coronary stenosis i.e. derived fractional flow reserve (FFR) <0.80), spontaneous coronary spasm (but not catheter related spasm), spontaneous coronary artery dissection
5. Other cardiovascular disorders - pulmonary hypertension, pulmonary embolism, hypertrophic cardiomyopathy, or valvular heart disease.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Association between invasive variable - Hyperaemic Microvascular Resistance (HMR) and non-invasive variable - left ventricular contractile reserve (CR)<br><br>HMR is measured by placing the Phillips Volcano ComboWire in the coronary artery, when use with ComboMap system. <br>CR is measured with strain imaging on low dose dobutamine stress echocardiography (DSE).[within 2 week at the end of the diagnostic coronary angiography.]
- Secondary Outcome Measures
Name Time Method