NCT05060783招募中不适用
Renal Cancer Detection With Liquid Biopsy
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- To identify the optimal GAG score
研究概览
简要总结
Glycosaminoglycans (GAGs) were significantly altered in localized as well advanced RCC compared to healthy samples. In addition, GAG scores correlated with progression-free survival and overall survival (OS) in a prospective cohort of patients with metastatic ccRCC and localized RCC. However, it is still unknown whether alterations in plasma and urine GAGs are exquisitely specific to RCC or are shared by other benign lesions in the kidney, such as angiomyolipomas, oncocytomas, or PEComa.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients who underwent CT-scan with suspicion of renal tumor and the scans show no sign of renal cancer.
- •For patient with ccRCC or oncocytoma, they should have a histological verified tumor (Biopsy or surgical specimen)
- •Sign up information consent
- •Can perform protocol procedure
排除标准
- •Non-clear cell Renal cell carcinoma
- •RCC with pure sarcomatoid differentiation, also called sarcoma of the kidney
- •Use of heparin for concurrent disease in need of blood dilution (e.g. ongoing deep vein thrombosis or lung emboli). Note: use of of heparin for thrombus prophylaxis in conjunction with primary surgery or postoperatively ≤4 weeks will be allowed.
结局指标
主要结局
To identify the optimal GAG score
时间窗: 2 years
To identify the optimal GAG score in healthy individuel
次要结局
未报告次要终点
研究者
Nessn Azawi
Associate professor
Zealand University Hospital
研究点 (1)
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