Exercise Rehabilitation of Younger and Older People With Claudication
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Intermittent Claudication
- Sponsor
- National Institute on Aging (NIA)
- Enrollment
- 64
- Locations
- 1
- Primary Endpoint
- Change in the walking distance to onset of leg pain, and the change in walking distance to maximal leg pain.
- Status
- Completed
- Last Updated
- 18 years ago
Overview
Brief Summary
The purpose of this study is to examine the effect of age and the effect of exercise intensity of rehabilitation programs on claudication pain symptoms and leg circulation of younger and older patients with intermittent claudication.
Detailed Description
Thirty-one patients randomized to low-intensity exercise rehabilitation and 33 patients randomized to high-intensity exercise rehabilitation completed the study. The 6-month exercise rehabilitation programs consisted of intermittent treadmill walking to near maximal claudication pain three days per week at either 40% (low-intensity group) or 80% (high-intensity group) of maximal exercise capacity. Total work performed in the two training regimens was similar by having the patients in the low-intensity group exercise for a longer duration than patients in the high-intensity group. Measurements of physical function, peripheral circulation, and health-related quality of life were obtained on each patient before and after the rehabilitation programs.
Investigators
Eligibility Criteria
Inclusion Criteria
- •History of intermittent claudication
- •Exercise tolerance limited by intermittent claudication during a screening treadmill test
- •Ankle/brachial index (ABI) at rest less than 0.90
- •Live independently at home
Exclusion Criteria
- •Absence of PAD (peripheral artery disease)
- •Asymptomatic PAD (Fontaine stage I)
- •Rest pain PAD (Fontaine stage III)
- •Exercise tolerance limited by factors other than claudication (e.g., coronary artery disease, dyspnea, poorly controlled blood pressure)
- •Active cancer, renal disease, or liver disease
- •Current use of pentoxifylline or cilostazol medications for the treatment of intermittent claudication
Outcomes
Primary Outcomes
Change in the walking distance to onset of leg pain, and the change in walking distance to maximal leg pain.
Time Frame: 6 months
Secondary Outcomes
- Changes in cardiopulmonary function, calf muscle circulation, and health-related quality of life.(6 months)