A Method to Optimize Mecanical In-exsufflation in Neuromuscular Diseases
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 40
- Locations
- 2
- Primary Endpoint
- optimal negative pressure treshold value
Study Overview
Brief Summary
The investigators want to demonstrate that there is an optimal expiratory pressure when using mecanical in-exsufflation for each patient in neuromuscular disease. This compromise is between the need to generate a high pressure difference between alveoli and the mouth and the need to avoide and superior airways collapsus.
Detailed Description
he investigators want to demonstrate that there is an optimal expiratory pressure when using mecanical in-exsufflation for each patient in neuromuscular disease. This compromise is between the need to generate a high pressure difference between alveoli and the mouth and the need to avoide and superior airways collapsus.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Treatment
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •man or female age18 years
- •neuromuscular disease
- •coughassist adaptation treatment
- •peak cough flow<270liter/minute
Exclusion Criteria
- •acute organ failure
- •insufflation contrindication
- •pregnant women/no affiliation to a social security scheme
- •plan of legal protection
Arms & Interventions
neuromuscular patients
Cough Assist® (JH Emerson Compagny, Cambridge, MA, USA)
Intervention: Cough Assist® (JH Emerson Compagny, Cambridge, MA, USA) (Device)
Outcomes
Primary Outcomes
optimal negative pressure treshold value
Time Frame: 20 minutes
Optimal negative pressure treshold value measured for a flow superior or equal to 160 liter/minute and 270 liter/minute
Secondary Outcomes
- optimal pressure treshold based on the best peak flow.(10 minutes)
- volume-flow curve aspect(5 minutes)