Determination of Optimal Positive End-expiratory Pressure Using Electrical Impedance Tomography in Children Under General Anesthesia: Comparison Between Supine and Prone Positions

Not Applicable

Completed

• Conditions: General Anesthesia

• Registration Number: NCT05275309
• Lead Sponsor: Seoul National University Hospital

Brief Summary

The purpose of this study was to determine the appropriate positive end-expiratory pressure (PEEP) using electrical impedance tomography (EIT) in children under general anesthesia and to investigate whether there is a difference between the supine and prone positions.

Detailed Description

Not available

Study Timeline

• Status Verified: 2021-11
• Study First Submitted: 2021-11-19
• Study First Submitted QC: 2022-03-01
• Study First Posted: 2022-03-11
• Study Start: 2022-03-14
• Primary Completion: 2022-12-30
• Study Completion: 2022-12-30
• Last Update Submitted: 2023-01-18
• Last Update Posted: 2023-01-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 33

Inclusion Criteria

• Children <= years of age who are scheduled for surgery in the prone position under general anesthesia

Exclusion Criteria

• Respiratory distress, bronchopulmonary dysplasia
• Pneumothorax
• Increased intracranial pressure
• History of airway surgery
• Cervical or thoracic surgery
• Pulmonary hypertension

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Optimal PEEP level at prone position	1 hour after prone positioning (prone)	Optimal PEEP level (cmH2O) determination using electrical impedance tomography at prone position
Optimal PEEP level at spine position	10 minutes after intubation (supine)	Optimal PEEP level (cmH2O) determination using electrical impedance tomography at supine position

Secondary Outcome Measures

Name	Time	Method
Dynamic compliance measured using Electrical impedance tomography	until 1 hour after prone positioning	ventilation/pressure (ml/cmH2O)
regional ventilation delay measured using Electrical impedance tomography	until 1 hour after prone positioning	ventilation time delay during one breath (no unit)
pulmonary opening pressure measured using Electrical impedance tomography	until 1 hour after prone positioning	alveoli opening pressure (cmH2O)
atelectasis/overdistension ratio measured using Electrical impedance tomography	until 1 hour after prone positioning	The degree comparing atelectasis and overdistension (no unit)

Trial Locations

Locations (1)

Hee-Soo Kim; 🇰🇷 Seoul, Korea, Republic of