A Method to Optimize Mecanical In-exsufflation in Neuromuscular Diseases
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- optimal negative pressure treshold value
研究概览
简要总结
The investigators want to demonstrate that there is an optimal expiratory pressure when using mecanical in-exsufflation for each patient in neuromuscular disease. This compromise is between the need to generate a high pressure difference between alveoli and the mouth and the need to avoide and superior airways collapsus.
详细描述
he investigators want to demonstrate that there is an optimal expiratory pressure when using mecanical in-exsufflation for each patient in neuromuscular disease. This compromise is between the need to generate a high pressure difference between alveoli and the mouth and the need to avoide and superior airways collapsus.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •man or female age18 years
- •neuromuscular disease
- •coughassist adaptation treatment
- •peak cough flow<270liter/minute
排除标准
- •acute organ failure
- •insufflation contrindication
- •pregnant women/no affiliation to a social security scheme
- •plan of legal protection
研究组 & 干预措施
neuromuscular patients
Cough Assist® (JH Emerson Compagny, Cambridge, MA, USA)
干预措施: Cough Assist® (JH Emerson Compagny, Cambridge, MA, USA) (Device)
结局指标
主要结局
optimal negative pressure treshold value
时间窗: 20 minutes
Optimal negative pressure treshold value measured for a flow superior or equal to 160 liter/minute and 270 liter/minute
次要结局
- optimal pressure treshold based on the best peak flow.(10 minutes)
- volume-flow curve aspect(5 minutes)