The efficacy and mechanisms of transcutaneous auricular vagus nerve stimulation on symptom in patients with IBS-C
Phase 1
- Conditions
- Constipation-dominant irritable bowel syndrome
- Registration Number
- ITMCTR2000002986
- Lead Sponsor
- Shanghai East Hospital Affiliated to Tongji University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria
1. Willing to sign informed consent;
2. Aged 18 to 75 years, regardless of gender;
3. Meets IBS-C Rome IV diagnostic criteria.
Exclusion Criteria
1. History of previous abdominal surgery related to IBS-C symptoms (except appendectomy);
2. Currently taking antidepressants, including tricyclic antidepressants and selective serotonin reuptake inhibitors;
3. Use of anticholinergics, antipsychotics or antispasmodics in the past 2 weeks;
4. Currently participating in another trial or in the past month;
5. Currently pregnant or planning to become pregnant;
6. Accompanied by severe heart, liver or kidney disease, or have diabetes;
7. Researchers do not consider it suitable for participants.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Visual Analogue Scale;Completely autonomous bowel movements;
- Secondary Outcome Measures
Name Time Method IBS symptom severity score;IBS Quality of Life Questionnaire;