Application and mechanism of transcutaneous auricular vagus nerve stimulation in disorder of consciousness after brain injury
Phase 1
Recruiting
- Conditions
- disorder of consiousness
- Registration Number
- ITMCTR2100005296
- Lead Sponsor
- Hangzhou normal university
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria
1. Aged >18years;
2. Subacute patients diagnosed as DOC by CRS-R;
3. No nerve stimulating drugs were used within 48 hours before enrollment;
4. No neuromuscular blocker was used within 24 hours before enrollment;
5. No facial or ear pain, no recent ear trauma, no metal implants, including pacemakers, no pregnancy.
Exclusion Criteria
1. Personal or family history of epileptic seizures, history of cardiovascular disease, history of developmental neurological or psychiatric disease;
2. Untreated brain edema;
3. Metal implants in the body;
4. Unstable vital signs;
5. MRI scan contraindications: such as claustrophobia.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Electroencephalogram;Behavior scale;
- Secondary Outcome Measures
Name Time Method telomere, proteins;Functional magnetic resonance;PET-glucose metabolism;