Comparison of the effects of different administration methods of ketamine on the early postoperative recovery quality of patients with colorectal cancer surgery

Phase 1

• Conditions: Colorectal Cancer

• Registration Number: ChiCTR2400088917
• Lead Sponsor: The First Affiliated Hospital of Anhui Medical University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2 September 2024

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

1. Patients undergoing elective colorectal cancer surgery in our hospital;<br>2. ASA classification I-III;<br>3. Normal communication and ability to understand instructions;<br>4. Expected postoperative stay without ICU admission;<br>5. Willingness to participate in the study and signing of informed consent form.

Exclusion Criteria

1. Severe respiratory or circulatory system diseases such as severe coronary artery disease, chronic obstructive pulmonary disease, etc.;<br>2. Contraindications to ketamine such as glaucoma, large vessel arterial aneurysm, etc.;<br>3. Functional impairments that prevent accurate participation in postoperative pain assessment;<br>4. Severe endocrine system diseases such as pituitary tumors, severe diabetes, etc.;<br>5. Mental health disorders such as schizophrenia, depression, epilepsy, history of chronic analgesic use, history of alcohol abuse, opioid dependence, etc.;<br>6. Inability to cooperate with the researchers for any reason, such as hearing or visual impairment, language comprehension difficulties, etc.;<br>7. History of Parkinson’s disease, stroke, Alzheimer’s disease, insomnia, severe hepatic dysfunction (Child C), renal dysfunction (preoperative dialysis), etc.

Study & Design

• Study Type: Interventional study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
15 recovery quality scores at 24 hours after surgery ;

Secondary Outcome Measures

Name	Time	Method
15 recovery quality scores at 48,72 hours after surgery ;Postoperative 24h, 48h, 72h Richards-Campbell Sleep Questionnaire scores ;Intraoperative and Critical Care Fatigue Score-10 ;VAS grade ;The intraoperative hemodynamics ;The dose of anesthetic drugs used ;Postoperative first bowel gas passage time ;Delirium Incidence Rate ;Frequency of Nausea and Vomiting ;