Javelin BRCA/ATM: Avelumab Plus Talazoparib in Patients With BRCA or ATM Mutant Solid Tumors

Phase 2

Terminated

Conditions: Genes, BRCA 1
Locally Advanced or Metastatic Solid Tumors

Interventions: Drug: Avelumab
Drug: Talazoparib

Registration Number: NCT03565991

Lead Sponsor: Pfizer

Brief Summary: Avelumab in combination with talazoparib will be investigated in patients with locally advanced or metastatic solid tumors with a BRCA or ATM defect.

Detailed Description: Avelumab is a human immunoglobulin (Ig)G1 monoclonal antibody (mAb) directed against programmed death ligand 1 (PD-L1). Avelumab selectively binds to PD-L1 and competitively blocks its interaction with programmed death receptor 1 (PD-1), thereby interfering with this key immune checkpoint inhibition pathway. Avelumab is currently being investigated as single agent and in combination with other anti cancer therapies in patients with locally advanced or metastatic solid tumors and various hematological malignancies.

Talazoparib is a potent, orally bioavailable poly (adenosine diphosphate \[ADP\] ribose) polymerase (PARP) inhibitor, which is cytotoxic to human cancer cell lines harboring gene mutations that compromise deoxyribonucleic acid (DNA) repair, an effect referred to as synthetic lethality, and by trapping PARP protein on DNA thereby preventing DNA repair, replication, and transcription.

Avelumab in combination with talazoparib will be investigated in patients with locally advanced (primary or recurrent) or metastatic solid tumors with a BReast CAncer susceptibility gene (BRCA)1, or BRCA2, or ataxia telangiectasia mutated (ATM) gene defect.

Recruitment & Eligibility

Status: TERMINATED

Sex: All

Target Recruitment: 202

Inclusion Criteria

BRCA1, BRCA2 and/or ATM gene defect.
Histological diagnosis of locally advanced (primary or recurrent) or metastatic solid tumors that are not amenable for treatment with curative intent
Availability a tumor tissue sample from a diagnostic biopsy/surgery or a metastatic tumor biopsy.
Progressive disease at study enrollment.
Minimum age 18 years (in Japan, minimum age 20 years).
ECOG performance status 0 or 1.
Adequate bone marrow, renal and liver function.
For childbearing female patients, negative serum or urine pregnancy test at screening
Signed and dated informed consent document.

Exclusion Criteria

Prior anti-cancer therapy or radiation therapy within 2 weeks prior to enrolment. Palliative radiotherapy to metastatic lesion(s) permitted providing that it has been completed at least 2 days prior to enrolment and no significant toxicity are expected.
Major surgery within 4 weeks prior to study enrollment.
Current use of immunosuppressive medication at the time of study enrollment.
Known prior severe hypersensitivity to investigational products or any component in their formulations
Known history of immune-mediated colitis, inflammatory bowel disease, pneumonitis, pulmonary fibrosis.
Active or prior autoimmune disease that might deteriorate when receiving an immunostimulatory agent.
Prior organ transplantation including allogenic stem-cell transplantation.
Administration of live attenuated vaccines within 4 weeks of study enrollment.
Diagnosis of myelodysplastic syndrome.
Known symptomatic brain metastases requiring steroids.
Persisting toxicity related to prior therapy Grade >1.
Known history of HIV or AIDS.
Positive HBV or HCV test indicating acute or chronic infection.
Active infection requiring systemic therapy.
Clinically significant (active) cardiovascular disease: cerebral vascular accident/stroke or myocardial infarction within 6 months prior to study enrollment; unstable angina, congestive heart failure or a serious cardiac arrhythmia requiring medication.
Diagnosis of any other malignancy within 2 years prior to study enrollment, except for adequately treated basal cell or squamous cell skin cancer, or carcinoma in situ of the breast, bladder, or cervix, or low-grade prostate cancer or other early-stage low-risk cancers.
Pregnant or breastfeeding female patients; female or male patients who are able to have children who are unable or unwilling to use contraception as outlined in the protocol.

Study & Design

Study Type: INTERVENTIONAL

Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Combination of avelumab and talazoparib	Avelumab	Single arm open label
Combination of avelumab and talazoparib	Talazoparib	Single arm open label

Primary Outcome Measures

Name	Time	Method
Percentage of Participants With Confirmed Objective Response (OR) as Assessed by Blinded Independent Central Review (BICR)	From the first dose of study treatment until the date of first documented disease progression or date of death from any cause, whichever came first, assessed up to approximately 24 months	For participants with solid tumors, except metastatic Castration Resistant Prostate Cancer (mCRPC), OR was defined as a complete response (CR) or partial response (PR) per Response Evaluation Criteria in Solid Tumors, version 1.1 (RECIST v1.1), both confirmed by repeat assessments performed no less than 4 weeks after the criteria for response were first met. For participants with mCRPC, OR was defined as the percentage of participants with a best overall soft tissue response of CR or PR per RECIST v1.1 with no evidence of confirmed bone disease progression per Prostate Cancer Working Group 3 (PCWG3) criteria. Per RECIST v1.1, CR was defined as complete disappearance of all target and non-target lesions with the exception of nodal disease. PR was defined as greater than or equal to 30% decrease under baseline of the sum of diameters of all target measurable lesions. Non-target PR lesions must be non-Progressive Disease (PD), where PD was unequivocal progression of pre-existing lesions.

Secondary Outcome Measures

Name	Time	Method
Serum Lowest (Trough) Concentration (Ctrough) of Avelumab	Predose on Day 1 of Cycles 1, 3, 6, 12, 18, 24 and Day 15 of Cycle 1	Ctrough was defined as predose concentration during multiple dosing. The determination method of Ctrough was observing directly from data. The lower limit of quantification (LLQ) was 0.2 mcg/mL. For Cycle 1 Day 1, as the number of observations above lower limit of quantification (NALQ) = 0, summary statistics were not presented.
Plasma Post-dose Concentrations for Talazoparib	Postdose (samples collected within 2 hours post dose plus/minus 12 minutes) on Days 1,15 of Cycle 1, and Day 1 of Cycle 3	In this OM, the post-dose concentrations for talazoparib in plasma were reported.
Plasma Ctrough for Talazoparib	Predose on Cycle 1 Days 1, 15 and Cycle 3 Day 1	Ctrough was defined as predose concentration during multiple dosing. The determination method of Ctrough was observing directly from data. The lower limit of quantification (LLQ) was 25 pg/mL. For Cycle 1 Day 1, as the number of observations above lower limit of quantification (NALQ) = 0, summary statistics were not presented. Evaluable participants were participants with non-missing Ctrough concentrations at each specific time point and meeting 2 conditions: participants received 14 consecutive days of talazoparib dose without dosing interruption prior to sample collection (except on Cycle 1 Day 1) and sample collection within 24 hours ± 10% (2 hours and 24 minutes) after the previous day's dose and no more than 5 minutes (0.083 hours) after the administration of the dose on the day of PK sample collection. Predose PK samples on Cycle 1 Day 1 must have been collected prior to dose.
Duration of Response (DoR) as Assessed by BICR	Baseline up to approximately 24 months	For participants with solid tumors, except mCRPC: DoR was defined for participants with confirmed objective response (CR or PR) as the time from the first documentation of objective tumor response to the first documentation of objective tumor progression or to death due to any cause, whichever occured first. For participants with mCRPC: DoR was defined for participants with confirmed objective response (CR or PR) as the time from the first objective evidence of soft tissue response (subsequently confirmed) per RECIST v1.1 and no evidence of confirmed bone disease progression by PCWG3 to the first subsequent objective evidence of radiographic progression or death due to any cause, whichever occured first. Radiographic progression was defined as soft tissue progression evaluated per RECIST v1.1 or bone disease progression evaluated per PCWG3.
Number of Participants With Neutralizing Antibodies (Nab) Levels Against Avelumab Ever-Positive	Predose (within 2 hours before start of avelumab infusion) on Day 1 of Cycles 1, 3, 6, 12, 18, 24 and Day 15 of Cycle 1	Nab ever-positive was defined as at least one positive Nab result at any time point. Samples positive for ADA with persistent treatment-induced ADA response could be analyzed for Nab.
Time to Tumor Response (TTR) as Assessed by BICR	Baseline up to approximately 24 months	For participants with solid tumors, except mCRPC: TTR was defined for participants with confirmed objective response (CR or PR) as the time from the first dose of study treatment to the first documentation of objective tumor response. For participants with mCRPC: TTR was defined as the time from the first dose of study treatment to the first objective evidence of soft tissue response with no evidence of confirmed bone disease progression on bone scan per PCWG3. Soft tissue response was defined as a Best Overall Response (BOR) of CR or PR per RECIST v1.1.
DoR as Assessed by Investigator	Baseline up to approximately 24 months	For participants with solid tumors, except mCRPC: DoR was defined for participants with confirmed objective response (CR or PR) as the time from the first documentation of objective tumor response to the first documentation of objective tumor progression or to death due to any cause, whichever occurred first. For participants with mCRPC: DoR was defined for participants with confirmed objective response (CR or PR) as the time from the first objective evidence of soft tissue response (subsequently confirmed) per RECIST v1.1 and no evidence of confirmed bone disease progression by PCWG3 to the first subsequent objective evidence of radiographic progression or death due to any cause, whichever occurred first. Radiographic progression was defined as soft tissue progression evaluated per RECIST v1.1 or bone disease progression evaluated per PCWG3.
Percentage of Participants With Confirmed OR as Assessed by The Investigator	From the first dose of study treatment until the date of first documented disease progression or date of death from any cause, whichever comes first, assessed up to approximately 24 months	For participants with solid tumors, except mCRPC, OR was defined as a CR or PR per RECIST v1.1, both confirmed by repeat assessments performed no less than 4 weeks after the criteria for response were first met. For participants with mCRPC, OR was defined as the percentage of participants with a best overall soft tissue response of CR or PR per RECIST v1.1 with no evidence of confirmed bone disease progression per PCWG3 criteria. Per RECIST v1.1, CR was defined as complete disappearance of all target and non-target lesions with the exception of nodal disease. PR was defined as greater than or equal to 30% decrease under baseline of the sum of diameters of all target measurable lesions. Non-target PR lesions must be non-PD, where PD was unequivocal progression of pre-existing lesions.
Number of Participants by Status of Tumor Mutational Burden (TMB) at Baseline	Baseline	TMB was defined as the total number of mutations in the tumor genome, or number of mutations per megabase of DNA if derived from targeted sequencing. TMB categories were defined as high, low for a number of mutations per megabase \>=10 and \<10, respectively. The TMB category 'Not analyzable' included participants with available samples but not evaluable. The TMB category 'Missing' included participants with no sample available. The number of participants in each category at only baseline were tabulated.
Number of Participants With Positive Programmed Death Ligand 1 (PD-L1) Expression in Baseline Tumor Tissue	Baseline	PD-L1 expression on tumor and infiltrating immune cells was measured by immunohistochemistry (IHC). PD-L1 expression level was defined as the number of PD-L1 positive cells and/or qualitative assessment of PD-L1 staining on tumor and inflammatory cells in regions of interest. This OM reported the number of participants classified as positive according to scoring algorithms and cut-offs established from external sources.
Number of Participants With Treatment-Emergent Adverse Events (TEAEs)	From baseline up to 30 days after last dose of study treatment, maximum up to 4.3 years approximately	An adverse event (AE) was any untoward medical occurrence in a clinical investigation where participants administered a product or medical device. TEAEs were those events with onset dates occurring during the on-treatment period. A Serious Adverse Event (SAE) was any untoward medical occurrence at any dose that: resulted in death, was life threatening, required inpatient hospitalization or prolongation of existing hospitalization, resulted in persistent or significant disability/incapacity, or resulted in congenital anomaly/birth defect. A treatment-related AE was any untoward medical occurrence attributed to the study drug in a participant who received study drug. TEAEs were graded by the investigator using National Cancer Institute Common Toxicity Criteria for Adverse Events (NCI CTCAE) v4.03 as Grade 1 = mild; Grade 2 = moderate; Grade 3 = severe; Grade 4 = life-threatening; Grade 5 = death related to AE.
Number of Participants With New or Worsening Hematology Laboratory Test Results During the On-Treatment Period	From baseline up to 30 days after last dose of study treatment, maximum up to 4.3 years approximately	The laboratory results were graded according to the CTCAE v4.03 severity grade whenever applicable. Laboratory test abnormalities were summarized according to worst toxicity grade observed for each laboratory test. As per NCI CTCAE toxicity grading v4.03, Grade 1 = mild; Grade 2 = moderate; Grade 3 = severe; Grade 4 = life-threatening; Grade 5 = death related to AE. On-treatment period was defined as the time from the first dose of study treatment through minimum (30 days + last dose of study treatment, start day of new anti-cancer drug therapy - 1 day).
Number of Participants With New or Worsening Chemistry Laboratory Test Results During the On-Treatment Period	From baseline up to 30 days after last dose of study treatment, maximum up to 4.3 years approximately	The laboratory results were graded according to the CTCAE v4.03 severity grade whenever applicable. Laboratory test abnormalities were summarized according to worst toxicity grade observed for each laboratory test. As per NCI CTCAE toxicity grading v4.03, Grade 1 = mild; Grade 2 = moderate; Grade 3 = severe; Grade 4 = life-threatening; Grade 5 = death related to AE. On-treatment period was defined as the time from the first dose of study treatment through minimum (30 days + last dose of study treatment, start day of new anti-cancer drug therapy - 1 day).
Serum Maximum Concentration (Cmax) for Avelumab	One hour post-dose on Day 1 of Cycles 1, 3, 6, 12, 18, 24 and Day 15 of Cycle 1	Cmax was defined as maximum observed plasma concentration. The determination method of Cmax was observing directly from data.
PFS as Assessed by Investigator	Baseline up to approximately 24 months	For participants with solid tumors, except mCRPC: PFS was defined as the time from the first dose of study treatment to the date of disease progression by RECIST v1.1 or death due to any cause, whichever occurred first. For participants with mCRPC: PFS was defined as the time from the first dose of study treatment to documentation of radiographic progression in soft tissue evaluated per RECIST v1.1, in bone evaluated per PCWG3, or death, whichever occurred first.
Number of Participants With Circulating Tumor Cell (CTC) Count Conversion	Day 1 of Cycle 1 to Cycle 4	For participants with mCRPC, CTC count conversion was defined as a decrease in CTC count from \>=5 CTC per 7.5 mL of blood at baseline to \<5 CTC per 7.5 mL of blood anytime on study.
Number of Participants by Avelumab Anti-drug Antibody (ADA) Categories	Predose (within 2 hours before start of avelumab infusion) on Day 1 of Cycles 1, 3, 6, 12, 18, 24 and Day 15 of Cycle 1	Blood samples were assayed for ADA using a validated assay. ADA never-positive = no positive ADA results at any time point. ADA ever-positive =at least one positive ADA result at any time point. Baseline ADA positive =a positive ADA result at baseline. Treatment-boosted ADA =a positive ADA result at baseline and the titer \>=8×baseline titer at least once after treatment with avelumab. Treatment-induced ADA = participant was ADA-negative at baseline and had at least one positive post-baseline ADA result; or the participant had at least one positive post-baseline ADA result if no baseline sample. Transient ADA response = participants with treatment-induced ADA had (a single positive ADA result or duration between first and last positive result \<16 weeks) and ADA result at the last assessment was not positive. Persistent ADA response =participants with treatment-induced ADA had duration between first and last positive ADA result \>=16 weeks or a positive ADA result at the last assessment.
TTR as Assessed by Investigator	Baseline up to approximately 24 months	For participants with solid tumors, except mCRPC: TTR was defined for participants with confirmed objective response (CR or PR) as the time from the first dose of study treatment to the first documentation of objective tumor response. For participants with mCRPC: TTR was defined as the time from the first dose of study treatment to the first objective evidence of soft tissue response with no evidence of confirmed bone disease progression on bone scan per PCWG3. Soft tissue response was defined as a BOR of CR or PR per RECIST v1.1.
Overall Survival (OS) for All Participants	Baseline up to approximately 24 months	OS was defined as the time from the first dose of study treatment to the date of death. Participants without an event (death) were censored at the date of last contact.
Time to Prostate-Specific Antigen (PSA) Progression for Participants With mCRPC	Baseline up to approximately 24 months	For participants with mCRPC, time to PSA progression was defined as the time from the first dose to the date that a \>=25% increase in PSA with an absolute increase of \>=2 μg/L (2 ng/mL) above the nadir (or baseline for participants with no PSA decline) was documented, confirmed by a second consecutive PSA value obtained \>=3 weeks (21 days) later.
Number of Participants With Cancer Antigen 125 (CA-125) Response	Baseline, Day 1 of each treatment Cycle, maximum up to 4.3 years approximately	For participants with ovarian cancer, CA-125 response was defined as at least a 50% reduction in CA-125 levels from baseline. The response must have been confirmed and maintained for at least 28 days.
Progression Free Survival (PFS) as Assessed by BICR	Baseline up to approximately 24 months	For participants with solid tumors, except mCRPC: PFS was defined as the time from the first dose of study treatment to the date of disease progression by RECIST v1.1 or death due to any cause, whichever occurred first. For participants with mCRPC: PFS was defined as the time from the first dose of study treatment to documentation of radiographic progression in soft tissue evaluated per RECIST v1.1, in bone evaluated per PCWG3, or death, whichever occurred first.
Number of Participants With Confirmed PSA Response	Baseline up to approximately 24 months	For participants with mCRPC, PSA response was defined as confirmed PSA decline \>=50% compared to baseline. PSA response was calculated as a decline from baseline PSA (ng/mL) to the maximal PSA response with a threshold of 50%. A PSA response must have been confirmed by a second consecutive value at least 3 weeks later.
Number of Participants With Different Status for Defects in BRCA1, BRCA2 and ATM	Baseline	Participants were enrolled in the two cohorts based on BRCA 1/2 and ATM defect status assessed by the local laboratory. The participant BRCA and ATM status was assessed retrospectively by central laboratory, that may differ from the status assessed by the local laboratory. The ATM participants with a negative ATM status per the central laboratory were reported to have a positive ATM status per the local laboratory. Therefore, participants with negative ATM status might have been included in the ATM defect cohort. For defects in BRCA1, BRCA2 and ATM by central laboratory analysis, participants were classified as positive, negative, not analyzable or missing. The number of participants in each category of BRCA 1 defect, BRCA 2 defect, BRCA 1 or BRCA 2 defect and ATM defect were presented.

Trial Locations

Locations (86): Northside Hospital, Inc. - GCS/Annex
🇺🇸
Atlanta, Georgia, United States
Northside Hospital, Inc. - GCS/Northside
🇺🇸
Atlanta, Georgia, United States
Atlanta Cancer Care - Atlanta
🇺🇸
Atlanta, Georgia, United States
Northside Hospital, Inc.-GCS/Stemmer
🇺🇸
Decatur, Georgia, United States
The Ohio State University Wexner Medical Center
🇺🇸
Columbus, Ohio, United States
Penn IDS Central
🇺🇸
Philadelphia, Pennsylvania, United States
Atlanta Cancer Care -Alpharetta
🇺🇸
Alpharetta, Georgia, United States
Northside Hospital, Inc.-GCS/Kennestone
🇺🇸
Marietta, Georgia, United States
Ochsner Clinic Foundation
🇺🇸
New Orleans, Louisiana, United States
Odense University Hospital
🇩🇰
Odense C, Denmark
Brigham and Women's Hospital
🇺🇸
Boston, Massachusetts, United States
Dana Farber Cancer institute
🇺🇸
Boston, Massachusetts, United States
The Sarah Cannon Research Institute
🇺🇸
Nashville, Tennessee, United States
The University of Texas
🇺🇸
Houston, Texas, United States
Istituto Europeo di Oncologia, Istituto di Ricovero e Cura a Carattere Scientifico
🇮🇹
Milano, MI, Italy
Fondazione Pascale, IRCCS, Istituto Nazionale dei Tumori
🇮🇹
Napoli, Italy
National Cancer Center Hospital
🇯🇵
Chuo-ku, Tokyo, Japan
Erasmus Universitair Medisch Centrum
🇳🇱
Rotterdam, Zuid-holland, Netherlands
Groupe Hospitalier La Rochelle-Ré-Aunis
🇫🇷
La Rochelle, France
IRCCS-Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST)
🇮🇹
Meldola, FC, Italy
Fondazione IRCCS, Istituto Nazionale dei Tumori
🇮🇹
Milano, MI, Italy
Universitair Ziekenhuis Antwerpen
🇧🇪
Edegem, Belgium
National Cancer Center Hospital East
🇯🇵
Kashiwa, Chiba, Japan
Fondazione Policlinico Universitario Agostino Gemelli Unità di Farmacologia Clinica
🇮🇹
Roma, Italy
Stanford Women's Cancer Center
🇺🇸
Palo Alto, California, United States
Stanford Healthcare
🇺🇸
Stanford, California, United States
Stanford Cancer Center
🇺🇸
Palo Alto, California, United States
Stanford University School of Medicine
🇺🇸
Stanford, California, United States
Northside Hospital, Inc. - GCS/Athens
🇺🇸
Athens, Georgia, United States
Northside Hospital, Inc. - Central Research Department
🇺🇸
Atlanta, Georgia, United States
Northside Hospital, Inc. - GCS/Canton
🇺🇸
Canton, Georgia, United States
Atlanta Cancer Care - Decatur
🇺🇸
Decatur, Georgia, United States
Atlanta Cancer Care - Stockbridge
🇺🇸
Jonesboro, Georgia, United States
Atlanta Cancer Care - Cumming
🇺🇸
Cumming, Georgia, United States
Northside Hospital, Inc.-GCS/Macon
🇺🇸
Macon, Georgia, United States
Siteman Cancer Center - West County
🇺🇸
Creve Coeur, Missouri, United States
Barnes-Jewish Hospital
🇺🇸
Saint Louis, Missouri, United States
Washington University Infusion Center Pharmacy
🇺🇸
Saint Louis, Missouri, United States
Siteman Cancer Center - St.Peters
🇺🇸
Saint Peters, Missouri, United States
Siteman Cancer Center - North County
🇺🇸
Saint Louis, Missouri, United States
Siteman Cancer Center - South County
🇺🇸
Saint Louis, Missouri, United States
Memorial Sloan Kettering Cancer Center - Investigational Drug Service Pharmacy
🇺🇸
Long Island City, New York, United States
Laura and Isaac Perlmutter Cancer Center at NYU Langone
🇺🇸
New York, New York, United States
Memorial Sloan Kettering Cancer Center- Monmouth
🇺🇸
Middletown, New Jersey, United States
Memorial Sloan Kettering Cancer Center- Westchester
🇺🇸
Harrison, New York, United States
Laura and Isaac Perlmutter Cancer Center
🇺🇸
New York, New York, United States
NY Investigational Pharmacy
🇺🇸
New York, New York, United States
NYU Langone Medical Center
🇺🇸
New York, New York, United States
NYU Langone Radiology - 32nd Street
🇺🇸
New York, New York, United States
NYU Langone Radiology Ambulatory Care Center East 41st Street
🇺🇸
New York, New York, United States
Memorial Sloan Kettering Cancer Center - David H. Koch Center for Cancer Care (74th Street).
🇺🇸
New York, New York, United States
Rockefeller Outpatient Pavilion (53rd Street)
🇺🇸
New York, New York, United States
Memorial Hospital
🇺🇸
New York, New York, United States
Rockefeller Outpatient Center
🇺🇸
New York, New York, United States
Evelyn H. Lauder Breast and Imaging Center
🇺🇸
New York, New York, United States
Memorial Sloan Kettering Cancer Center
🇺🇸
New York, New York, United States
White Plains Hospital
🇺🇸
White Plains, New York, United States
Martha Morehouse Medical Plaza
🇺🇸
Columbus, Ohio, United States
The Ohio State University
🇺🇸
Columbus, Ohio, United States
Stephanie Spielman Comprehensive Breast Cancer
🇺🇸
Columbus, Ohio, United States
OSU Gynecologic Oncology at Mill Run
🇺🇸
Hilliard, Ohio, United States
Stephenson Cancer Center
🇺🇸
Oklahoma City, Oklahoma, United States
Hospital of the University of Pennsylvania/Penn Investigational Drug Services
🇺🇸
Philadelphia, Pennsylvania, United States
Hospital of the University of Pennsylvania
🇺🇸
Philadelphia, Pennsylvania, United States
Magee-Women's Hospital Women's Cancer Center
🇺🇸
Pittsburgh, Pennsylvania, United States
UPMC Hillman Cancer Center Investigational Drug Service
🇺🇸
Pittsburgh, Pennsylvania, United States
UPMC Hillman Cancer Center
🇺🇸
Pittsburgh, Pennsylvania, United States
Tennessee Oncology, PLLC
🇺🇸
Smyrna, Tennessee, United States
Institut Jules Bordet
🇧🇪
Brussels, Belgium
UZ Brussel
🇧🇪
Brussel, Belgium
Rigshospitalet
🇩🇰
Copenhagen, Denmark
Centre Jean Perrin
🇫🇷
Clermont Ferrand, France
Institut Regional du Cancer de Montpellier - ICM Val d'Aurelle
🇫🇷
Montpellier Cedex 5, France
Presidio AO-U, Ospedali Riuniti Umberto I - G.M. Lancisi - G. Salesi
🇮🇹
Torette Di Ancona, AN, Italy
Azienda Socio-Sanitaria Territoriale Monza, Ospedale San Gerardo
🇮🇹
Monza, MB, Italy
Azienda Policlinico Umberto I, Universita La Sapienza, Oncologia B
🇮🇹
Roma, Italy
Osaka International Cancer Institute
🇯🇵
Osaka-shi, Osaka, Japan
Amsterdam University Medical Centre, location VUmc
🇳🇱
Amsterdam, Noord Holland, Netherlands
Hospital Universitario Vall d'Hebron
🇪🇸
Barcelona, Spain
Clinica Universidad de Navarra
🇪🇸
Madrid, Spain
Hospital Universitario Virgen de Valme
🇪🇸
Sevilla, Spain
Barts Health NHS Trust, St Bartholomew's Hospital
🇬🇧
London, United Kingdom
Sarah Cannon Research Institute UK
🇬🇧
London, United Kingdom
Washington University School of Medicine
🇺🇸
Saint Louis, Missouri, United States
H.G.U. Gregorio Maranon
🇪🇸
Madrid, Spain
H.U. Fundación Jiménez Díaz
🇪🇸
Madrid, Spain