Cerebral Microdialysis in Patients With Fulminant Hepatic Failure

Completed

• Conditions: Fulminant Hepatic Failure
• Interventions: Procedure: no intervention

• Registration Number: NCT00836420
• Lead Sponsor: Rigshospitalet, Denmark

Brief Summary

Patients with fulminant hepatic failure (FHF) often develop cerebral edema, high intracranial pressure (ICP)that may result in fatal brain damage. The aim in this protocol is to determine if a rise in the brain concentration of glutamate, lactate and pyruvate are involved in development of surges of high ICP in patients with FHF. The study is observatory in nature and also record the influence of any intervention that may e instituted during the course of the critical illness.

Detailed Description

Fulminant hepatic failure (FHF) is often complicated by cerebral edema, high intracranial pressure (ICP) and brain death. Accordingly the intracranial pressure is often monitored in such patients in order to be able to institute treatment before high ICP evolves. As routinely done in patients with severe head injury a microdialysis monitoring catheter is also placed under this procedure to measure metabolic changes that are responsible for surges of high ICP. The aim in this descriptive protocol is to determine if a rise in glutamate, lactate and pyruvate concentration in the brain cortex are involved in development of surges of high ICP in patients with FHF. The study is observatory in nature and also record the influence of any intervention during the course of the critical illness.

Study Timeline

• Study Start: 2000-01
• Study First Submitted: 2009-02-03
• Study First Submitted QC: 2009-02-03
• Study First Posted: 2009-02-04
• Status Verified: 2015-10
• Primary Completion: 2015-10
• Study Completion: 2015-10
• Last Update Submitted: 2015-10-26
• Last Update Posted: 2015-10-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• All patients with fulminant hepatic failure

Exclusion Criteria

• Age below 18 years
• Pregnancy
• Not obtained informed consent
• Suspicion of cancer disease
• No pupil reaction to light

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
liver	no intervention	patients with acute liver failure

Primary Outcome Measures

Name	Time	Method
Brain lactate concentration and intracranial hypertension	2013	to determine if brain oxidative metabolism correlates with brain edema and high intracranial pressure

Trial Locations

Locations (1)

Rigshospitalet Dept Hepatology A-2121; 🇩🇰 Copenhagen, Denmark