effect of eptifibatide and reteplase on primary angioplasty outcomes
- Conditions
- Acute Myocardial Infarction.Acute myocardial infarction
- Registration Number
- IRCT20170925036401N1
- Lead Sponsor
- Rasht University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 160
ischemic tipic chest pain extending more than 30 min, STelevation more than 1 mm in at least 2 leads with the same name, all patients with STEMI candidate for primary PCI, myocardial infarction not extending more than 12 hours, having life expectancy not less than 6 months, consent for participation in the study, age 18 to 80 years, no evidence for prior myocardial infarction, not having contraindications for reteplase or eptifibatide, not having left bundle branch block, not using GPIIb/IIIa in recent two weeks.
rescue PCI after thrombolytic therapy, emergency CABG, cardiogenic shock, atrial fibrillation TIMI flow grade 3 in primary angiography(ie, having normal blood flow in coronary arteries) simultaneously presence in another intervention study
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Coronary blood flow. Timepoint: before and after primary PCI. Method of measurement: based on angiographic scale TIMI blush grade.
- Secondary Outcome Measures
Name Time Method eft ventricular diastolic dysfunction change. Timepoint: before and after angiography. Method of measurement: according to echocardiographic criteria.;ST resolution average. Timepoint: before and 90 minutes after PCI. Method of measurement: based on electrocardiogram.;Average of EF changes. Timepoint: before and 3 to 4 days after angioplasty. Method of measurement: based on echocardiography.