NCT03281473Unknown不适用
Comparison of Positive End Expiratory Pressure Titration Methods in Patients With Acute Respiratory Distress Syndrome: a Physiological Study
University Hospital, Angers1 个研究点 分布在 1 个国家目标入组 20 人开始时间: 2018年10月2日最近更新:
适应症
干预措施
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Short-term effects of 2 PEEP titration strategies on gas exchange
研究概览
简要总结
This study aims at assessing the short-term physiological effects of 2 positive end expiratory pressure titration strategies in patients with ARDS.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age> 18 years
- •Moderate or severe ARDS
- •Consent to participation obtained from a relative
排除标准
- •Protect adult
- •Pregnant or breastfeeding woman
- •No-affiliation to the social security scheme
- •Contra-indication to the placement of an esophageal pressure measuring catheter
- •Pneumothorax
- •Hemodynamic and / or respiratory instability
- •Extra-corporeal membrane oxygenation
研究组 & 干预措施
Arms A
Experimental
Strategy 1 - Washout period - Strategy 2
干预措施: Strategy 1 (Other)
Arms A
Experimental
Strategy 1 - Washout period - Strategy 2
干预措施: Strategy 2 (Other)
Arms B
Experimental
Strategy 2 - Washout period - Strategy 1
干预措施: Strategy 1 (Other)
Arms B
Experimental
Strategy 2 - Washout period - Strategy 1
干预措施: Strategy 2 (Other)
结局指标
主要结局
Short-term effects of 2 PEEP titration strategies on gas exchange
时间窗: 2 hours 15 minutes
次要结局
- Short-term effects of 2 PEEP titration strategies on hemodynamics(2 hours 15 min)
- Short-term effects of 2 PEEP titration strategies on respiratory mechanics(2 hours 15 min)
研究者
研究点 (1)
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