The Relationship Between Peripheral Artery Plaque Characteristics Evaluated by Ultrasound and Coronary Culprit Lesion Characteristics Evaluated by OCT in ACS Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 350
- 试验地点
- 1
- 主要终点
- Differences in ultrasound parameters of peripheral artery plaque according to different coronary culprit lesion morphology.
研究概览
简要总结
This study aims at evaluating the relationship between peripheral artery plaque characteristics evaluated by ultrasound and coronary culprit lesion characteristics evaluated by OCT in ACS patients.
详细描述
Patients with acute coronary syndrome (ACS) who underwent percutaneous coronary intervention (PCI) and optical coherence tomography (OCT) are included in this study. Two skillful echocardiographers will evaluate peripheral artery plaque characteristics by ultrasound.Ultrasound parameters of peripheral artery will be compared among patients with different coronary culprit lesion characteristics, such as plaque rupture and plaque erosion.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosed as ACS underwent coronary angiography and OCT examination
- •Agreed to accept peripheral artery ultrasound examination
排除标准
- •In-stent restenosis, coronary dissection, coronary spam, thrombus
- •left main artery disease
- •Age>85 years old
- •Cardiogenic shock or stroke admission
- •Severe hepatic or renal dysfunction
- •Poor quality of OCT image or massive thrombus
结局指标
主要结局
Differences in ultrasound parameters of peripheral artery plaque according to different coronary culprit lesion morphology.
时间窗: Baseline
Plaque rupture is characterized by the presence of fibrous cap discontinuity with a cavity formation. plaque erosion is characterized by the presence of the attached thrombus overlying an intact and visual plaque, luminal surface irregularity at the culprit lesion in the absence of thrombus, or attenuation of the underlying plaque by thrombus without superficial lipid or calcification immediately proximal or distal to the site of thrombus.Patients with plaque erosion have less plaques, lower intima-media thickness (IMT), lower plaque score (PS) compared to patients with plaque rupture.
次要结局
未报告次要终点
研究者
Yu Bo
Director of Cardiology of The Seconf Affiliated Hospital of Harbin Mdical University
Harbin Medical University