The Relationship Between Peripheral Arterial Disease and Mitochondrial Respiratory Capacity

Completed

• Conditions: Intermittent Claudication

• Registration Number: NCT02434783
• Lead Sponsor: Norwegian University of Science and Technology

Brief Summary

Current evidence cannot explain the clinical features of peripheral arterial disease only from the principle of reduced blood flow. Explanations have therefore in addition been linked to mitochondrial dysfunction of skeletal muscles.

This study will elucidate whether there is a relation between clinical variables of the different levels of arterial insufficiency in peripheral arterial disease and mitochondrial respiratory capacity.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2015-04-30
• Study First Submitted QC: 2015-04-30
• Study Start: 2015-05
• Study First Posted: 2015-05-05
• Primary Completion: 2016-04
• Study Completion: 2016-04
• Status Verified: 2016-08
• Last Update Submitted: 2016-08-04
• Last Update Posted: 2016-08-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 16

Inclusion Criteria

• Asymptotic peripheral arterial disease (Ankle-brachial index < 0.9), intermittent claudication (Ankle-brachial index 0.4 - 0.9), or critical limb ischemia (Ankle-brachial index < 0.4)

Exclusion Criteria

• Diagnosed with intermittent claudication secondary to vascular insufficiency
• Warfarin or heparin usage
• Underwent a vascular intervention in the last 6 months
• Active cancer, renal- or liver disease

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
mitochondrial respiratory capacity	1 hour	measured in oxygen glux in pmol.s-1.mg-1, using mitochondrial respirometry on an Oxygraph-2k (Oroboros Instruments, Austria).

Trial Locations

Locations (1)

Department of Circulation and Medical Imaging; 🇳🇴 Trondheim, Norway