EVALUATION OF LUNG DYNAMICS AND RESPIRATORY FUNCTIONS IN PATIENTS APPLIED WITH MINIMAL FLOW ANESTHESIA: A PROSPECTIVE, RANDOMIZED STUDY
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Dynamic Compliance assessment
研究概览
简要总结
The patients were randomized into two groups medium flow anesthesia (MeFA) and minimal flow anesthesia (MiFA). While MeFA received medium flow anesthesia with 2 lt/min, MiFA received minimal flow anesthesia with 0.5 lt/min fresh gas flow. In both groups dynamic compliance values, peak inspiratory pressure (PIP) values, total inhalation anesthetic drug consumption, total remifentanil drug consumption, duration of anesthesia, and duration of surgery were recorded. The FVC, FEV1, and FEV1/FVC values of the patients in both groups were evaluated and noted 24 hours before the operation, after the operation 2nd, 8th, and 24th hours.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Screening
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •18-65 years of age, who will undergo elective laparoscopic cholecystectomy surgery
排除标准
- •ASA III-IV
- •Body mass index (BMI) > 40 kg / m2,
- •Patients with cardiovascular system disease
- •Chronic respiratory diseases,
- •Patients whose pulmonary function tests cannot be applied and who have problems with pulmonary function tests during the examination of the chest disease consultant
研究组 & 干预措施
Minimal flow anesthesia
After reaching the MAC 1 value with 4 lt/min 50% O2 - 50% air and 8% desflurane minimal flow anesthesia was started with 0.50 lt/min 50% O2 - 50% air with MAC 1 concentration of desflurane.
干预措施: Minimal flow anesthesia (Other)
Medium flow anesthesia
After reaching the MAC 1 value with 4lt/min 50% O2 - 50% air and 8% desflurane medium flow anesthesia was started with 2 lt/min 50% O2 - 50% air with MAC 1 concentration desflurane.
干预措施: Medium flow anesthesia (Other)
结局指标
主要结局
Dynamic Compliance assessment
时间窗: immediately after the end of the surgical suturing
Dynamic Compliance will be assessed immediately after the end of the surgical suturing
Peak inspiratory pressure assessment
时间窗: immediately after the end of the surgical suturing
Peak inspiratory pressure will be assessed immediately after the end of the surgical suturing
Dynamic Compliance assessment
时间窗: 5th minutes after endotracheal intubation
Dynamic Compliance will be assessed 5th minutes after endotracheal intubation
Dynamic Compliance assessment
时间窗: 5th minutes after surgical incision
Dynamic Compliance will be assessed 5th minutes after the surgical incision
Dynamic Compliance assessment
时间窗: 10th minutes after surgical incision
Dynamic Compliance will be assessed 10th minutes after the surgical incision
Dynamic Compliance assessment
时间窗: 30th minutes after surgical incision
Dynamic Compliance will be assessed 30th minutes after the surgical incision
Dynamic Compliance assessment
时间窗: 60th minutes after surgical incision
Dynamic Compliance will be assessed 60th minutes after the surgical incision
Peak inspiratory pressure assessment
时间窗: 5th minutes after endotracheal intubation
Peak inspiratory pressure will be assessed 5th minutes after endotracheal intubation
Peak inspiratory pressure assessment
时间窗: 5th minutes after the surgical incision
Peak inspiratory pressure will be assessed 5th minutes after the surgical incision
Peak inspiratory pressure assessment
时间窗: 10th minutes after the surgical incision
Peak inspiratory pressure will be assessed 10th minutes after the surgical incision
Peak inspiratory pressure assessment
时间窗: 30th minutes after the surgical incision
Peak inspiratory pressure will be assessed 30th minutes after the surgical incision
Peak inspiratory pressure assessment
时间窗: 60th minutes after the surgical incision
Peak inspiratory pressure will be assessed 60th minutes after the surgical incision
次要结局
- FEV1 measures assessment(24th hour after the operation)
- FEV1/FVC measures assessment(24th hour after the operation)
- FVC measures assessment(24th hour after the operation)
- FEV1 measures assessmentt(8th hour after the operation)
- FEV1 measures assessment(24 hours before the operation)
- FEV1 measures assessment(2nd hour after the operation)
- FVC measures assessment(24 hours before the operation)
- FVC measures assessment(2nd hour after the operation)
- FVC measures assessment(8th hour after the operation)
- FEV1/FVC measures assessment(24 hours before the operation)
- FEV1/FVC measures assessment(2nd hour after the operation)
- FEV1/FVC measures assessment(8th hour after the operation)
研究者
Erkan Cem ÇELİK
Associate Professor
Ataturk University