The Cholelithiasis in Adults With Short Bowel Syndrome

Completed

• Conditions: Short Bowel Syndrome

• Registration Number: NCT04867538
• Lead Sponsor: Jinling Hospital, China

Brief Summary

Short-term studies have shown that patients with short bowel syndrome (SBS) often develop cholestasis or cholelithiasis. In this retrospective cohort study, we aimed to define the incidence, risk factors, and clinical consequences of cholelithiasis in adults with SBS over an extended time period.

Detailed Description

However, only limited data are available regarding cholelithiasis in patients with SBS. The prevalence of cholelithiasis in patients with SBS has been reported only in two studies. Furthermore, few studies have focused on identifying the risk factors for cholelithiasis in patients with SBS. Considering the marked improvements in medical care and nutrition support during the last 2 decades, the current incidence and risk factors for cholelithiasis in patients with SBS are unknown.

The aim of the current study was to provide comprehensive, longitudinal, and long-term data on the incidence of symptomatic and asymptomatic cholelithiasis in a cohort of patients with SBS, in order to identify the prevalence, risk factors, and clinical consequences of cholelithiasis in patients with SBS to aid in the development of protective interventions.

Study Timeline

• Study Start: 2010-01-01
• Primary Completion: 2019-12-31
• Study Completion: 2020-12-31
• Status Verified: 2021-04
• Study First Submitted: 2021-04-27
• Study First Submitted QC: 2021-04-27
• Last Update Submitted: 2021-04-27
• Study First Posted: 2021-04-30
• Last Update Posted: 2021-04-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 345

Inclusion Criteria

All eligible adults diagnosed with SBS

Exclusion Criteria

age <18 years; history of cholelithiasis before SBS diagnosis; cholecystectomy; biliary tract obstruction or no abdominal imaging (CT, MRI, or ultrasound) after SBS diagnosis.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
the incidence of cholelithiasis in patients with SBS	2010/1/1-2019/12/31	the incidence of symptomatic and asymptomatic cholelithiasis in a cohort of patients with SBS
risk factors	2010/1/1-2019/12/31	the risk factors of cholelithiasis in patients with SBS
complications	2010/1/1-2019/12/31	the clinical consequences of cholelithiasis in patients with SBS