Effect of ayurvedic medicines (Punarnavadi Kwath and Navaka Guggulu) in Obesity.

Phase 3

Not yet recruiting

• Conditions: Obesity, unspecified. Ayurveda Condition: MEDOROGAH,

• Registration Number: CTRI/2021/05/033808
• Lead Sponsor: Chaudhary Brahm Prakash Ayurved Charak Sansthan

Brief Summary

Medoroga means a disease in which Medo dhatu is deranged and known as Medo dushti. Main involving Dosha and Dushya in Medoroga Samprapti are Kapha Dosha and Medo dhatu which leads to Medovaha Sroto dushti.It occurs due to lack of physical exercise ,sleeping day time and intake of kapha increasing diet  are converted into sneha (fatty acids) which leads to increase of fat,since the increased meda blocks channels and  other dhatus are not properly nourished as a result fat is further increased and the person become incapable of daily routine activities efficiently. Due to exceesive increase in Meda and Mamsa the person’s buttocks,belly and breasts become pendulous and his vigour is depleted. Medoroga may be correlated with obesity in modern medical science.

Obesity is abnormal or excessive fat accumulation that may impair health .Overweight is a BMI greater than or equal to 25 kg/m2 and a BMI greater than or equal to 30 kg/m2 is defined as obesity.

This study is aimed to compare the efficacy of Punarnavadi kwath and Navaka Guggulu in reduction of BMI and Lipid profile. total number of Patients is 80 .40 in each group .In group A , punarnavadi kwath orally 40ml twice a day empty stomach in morning and 4 hours after lunch , In group B Navaka Guggulu orally 2 tab twice a day ,1 hour after meals in morning and evening.

Criteria for Assessment-1)Subjective Parameters - Scoring Pattern will be adopted to obtain the percentage relief for sign and symptoms of Medoroga to assess the efficacy of therapy.

2)Objective Parameters-Weight, BMI scale, Waist circumfrence ,Hip Circumference, Waist Hip Ratio, Lipid Profile.

Lab investigations- Lipid profile ,it includes Serum Total Cholesterol, S. Triglycerides, S. LDL, S.VLDL, S.HDL .

Expected Outcome variables -Reduction in weight, BMI, Waist circumference , Hip circumference ,Waist Hip Ratio,, Serum VLDL,S. LDL,S. Triglycerides,S. Total Cholesterol and an increase in Serum HDL. Reduction in percentage relief in subjective criteria of Medoroga.

Statistical Analysis- by Z test and other tools as per requirement at the end of study period.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-03-06
• Last Update Posted: 2021-11-05

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• 1)BMI ranging from 30 to 40 kg/m2 2)Patient having few or more of the clinical features of Medoroga.
• Short (repeated) breathing -Thirst -Delusions -Sleepiness -Suddden obstruction to breath -Laxity of the body -Excessive Hunger and Sweating -Foul Odour of the body -Decreased Vitality -Decreased Sexual Power of the Body 3)Patient willing to partcipate and provide signed informed consent.

Exclusion Criteria

• 1)Patients reporting with known case of serious renal,hepatic and cardiac anomalies.
• 2)pregnant and lactating women 3)patients having any malignancy 4)patients who are not willing to participate with study.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Reduction in Scoring Patterns of sign and sypmtoms of Medoroga.	Day 1 | Day 15 | Day 30 | Day 45
1) Chala Sphika Udara Stana	Day 1 | Day 15 | Day 30 | Day 45
2)Alasya/Utsah hanilack of Zest)	Day 1 | Day 15 | Day 30 | Day 45
3)Kshudra Shwasa(Difficulty in Breathing)	Day 1 | Day 15 | Day 30 | Day 45
4)Daurbalya(weakness)	Day 1 | Day 15 | Day 30 | Day 45
5)Nidra adhikya(Excessive Sleeping)	Day 1 | Day 15 | Day 30 | Day 45
6)Swedadhikya(Excessive sweating)	Day 1 | Day 15 | Day 30 | Day 45
7)Daurgandhya(Bad Odour)	Day 1 | Day 15 | Day 30 | Day 45
8)Snigdhangata(oil lustre of body)	Day 1 | Day 15 | Day 30 | Day 45
9)Atipipasa(Excessive Thirst)	Day 1 | Day 15 | Day 30 | Day 45
10)Atikshuda(Excessive Hunger)	Day 1 | Day 15 | Day 30 | Day 45
11)Angagaurava(Heaviness of body)	Day 1 | Day 15 | Day 30 | Day 45

Secondary Outcome Measures

Name	Time	Method
Reduction in weight,BMI,Waist circumference,Hip Circumference,Waist Hip Ratio,Serum Reduction in weight,BMI,Waist circumference,Hip Circumference,Waist Hip Ratio,Serum VLDL,S.LDL,S.Triglycerides,S.Total Cholesterol,and an increase in Serum HDL	Day 1

Trial Locations

Locations (1)

Chaudhary Brahm Prakash Ayurved Charak Sansthan; 🇮🇳 West, DELHI, India

Chaudhary Brahm Prakash Ayurved Charak Sansthan

🇮🇳West, DELHI, India

Prof Dr NR singh

Principal investigator

9560659728

naimishraj@yahoo.com