Study on the Application of Tumor Exosome Liquid Biopsy in the Early Diagnosis of Pancreatic Cancer
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 发起方
- 入组人数
- 400
- 试验地点
- 1
- 主要终点
- Characterization of proteins in tumor exosomes from patients with pancreatic cancer
研究概览
简要总结
This is an observational study of patients diagnosed with pancreatic cancer by pathology, with a control group of patients with pathology suggestive of benign pancreatic lesions and normal subjects, and the diagnostic ability of exosomes to identify patients with pancreatic cancer was assessed through the detection of exosomes in the peripheral blood.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Diagnosis of pancreatic cancer confirmed by imaging (case) Diagnosis of chronic pancreatitis confirmed by imaging (hospital control)
排除标准
- •The pathology diagnosis and imaging does not matched Patients with other malignant tumors Patients with other severe systemic diseases
结局指标
主要结局
Characterization of proteins in tumor exosomes from patients with pancreatic cancer
时间窗: Up to 2 years from start of study
We will select specific protein A from circulating exosomes of pancreatic cancer patients for further analysis.
The expression of protein A in the circulating exosomes from patients
时间窗: Up to 2 years from start of study
By detecting the expression of protein A in circulating exosomes of patients. the ROC curve of A+ circulating exosomes will be compared to clinical standard tumor biomarkers (e.g., CA199) in pancreatic cancer patients.
次要结局
未报告次要终点
研究者
Yingbin Liu, MD, PhD, FACS
vice-president，Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
Shanghai Jiao Tong University School of Medicine