Exploratory Investigation of Advanced PET/MRI Metrics for Bladder Cancer Characterization
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 24
- 试验地点
- 1
- 主要终点
- Tumor standardized uptake value (SUV) from 18-fluorodeoxyglucose PET/MRI scan
研究概览
简要总结
The overarching goal of this project is to explore whether associations exist between metrics obtained from PET/MRI incorporating advanced MRI sequences and features of bladder cancer, including grade, stage, and treatment response.
详细描述
The investigators will assess an advanced non-Gaussian diffusion-weighted imaging (DWI) model termed diffusion kurtosis imaging, multi-echo T2 mapping, dynamic contrast-enhanced (DCE) MRI using a motion-robust high-temporal and high-resolution radial acquisition scheme employing compressed sensing, and simultaneously acquired 18-fluoro (18F)- fluorodeoxygluclose (FDG) data. Preliminary data demonstrates the investigators ability to execute and evaluate all of these techniques at the investigators center. The investigators hypothesize that these techniques will be sensitive to functional and metabolic differences between subsets of bladder cancer cases and will improve upon the performance of current imaging protocols in bladder cancer characterization. Moreover, the investigators believe that these techniques will provide complementary information, such that they may be combined in a synergistic fashion for bladder cancer evaluation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Histologic or imaging evidence of urothelial carcinoma of the bladder
- •Age ≥ 18 years of age
- •If female of childbearing potential, pregnancy test is negative. (In these instances, the patient will need to provide documentation of negative pregnancy test results.)
排除标准
- •Inability to tolerate MRI including conditions such as claustrophobia or inability to lay flat for > 45 minutes.
- •Presence of pacemaker/implantable cardiac device (ICD) or perfusion pumps
- •Ferromagnetic implants such as aneurysm clips, surgical clips, prostheses, artificial heart, valves with steel parts, metal fragments, shrapnel, bullets, tattoos near the eye, or steel implants.
- •Substance abuse, medical, psychological, or social conditions that may interfere with the patient's participation in the study
研究组 & 干预措施
PET/MRI
Patient receives MRI
干预措施: PET/MRI (Procedure)
结局指标
主要结局
Tumor standardized uptake value (SUV) from 18-fluorodeoxyglucose PET/MRI scan
时间窗: within one week of study completion
The tumor SUV value obtained approximately one hour following 18-fluorodeoxyglucose administration will be measured.
次要结局
未报告次要终点