Validation of Combined PET-MR Quantitative Parameters for Cardiac Applications
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Cardiac Disease
- Sponsor
- University of California, San Francisco
- Enrollment
- 2
- Locations
- 1
- Primary Endpoint
- Number of Quality PET and PET/MR Images With Regional Myocardial Uptake of 18F-Fluorodeoxyglucose (FDG) in Participants Without Overt Diagnosis of Ischemic Coronary Artery Disease.
- Status
- Terminated
- Last Updated
- 4 years ago
Overview
Brief Summary
The purpose of this study is to understand how simultaneous PET/MR acquisition can provide novel qualitative and quantitative biomarkers to guide clinical intervention and predict prognosis of patients with cardiovascular disease.
Detailed Description
* To compare regional myocardial uptake of FDG on images obtained on a standard PET camera with the new PET/MR camera, in patients with coronary artery disease. * To compare viability maps obtained with cardiac MR images and FDG-PET for delineation of myocardial infarct core and border zone, in patients with coronary artery disease. * To correlate MRI myocardial strain with relative myocardial FDG uptake in patients with a previous myocardial infarction. * To interrogate if simultaneous acquisition of cardiac PET and viability cardiac MR differ from acquisitions obtained independently, with special focus on attenuation correction methods * To combined MRI scar map with FDG-PET uptake in patients with cardiac sarcoidosis and myocarditis. * To correlate morphologic characteristics of atherosclerotic disease in the thoracic and abdominal aorta with FDG uptake and ferumoxytol enhancement, as a marker of inflammation. * To evaluate cardiac strain and myocardial scar burden in obese patients with and without diabetes.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Subjects with ischemic and non-ischemic cardiac disease referred for cardiac PET for viability imaging.
Exclusion Criteria
- •Contraindications for MRI, including cardiac pacemaker, claustrophobia, retained metallic foreign body, cochlear implant, Aneurysm clip in the brain, pregnancy and eGFR less than 45%.
Outcomes
Primary Outcomes
Number of Quality PET and PET/MR Images With Regional Myocardial Uptake of 18F-Fluorodeoxyglucose (FDG) in Participants Without Overt Diagnosis of Ischemic Coronary Artery Disease.
Time Frame: 2 hours
Visual analysis of collected image pairs. Evaluated by experienced imaging providers as yes or no.