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Clinical Trials/NCT04164680
NCT04164680
Completed
Not Applicable

Relationship Between Simultaneously Acquired Resting-state Regional Cerebral Glucose Metabolism and Functional MRI in DOC: a PET/MR Hybrid Scanner Study

Hangzhou Normal University1 site in 1 country24 target enrollmentJanuary 1, 2018

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Disorder of Consciousness
Sponsor
Hangzhou Normal University
Enrollment
24
Locations
1
Primary Endpoint
fludeoxyglucose (FDG-)PET
Status
Completed
Last Updated
3 years ago

Overview

Brief Summary

Recently introduced hybrid PET/MR scanners provide the opportunity to measure simultaneously, and in direct spatial correspondence, both metabolic demand and functional activity of the brain, hence capturing complementary information on the brain's physiological state. Here we exploited PET/MR simultaneous imaging to explore the relationship between the metabolic information provided by resting-state fluorodeoxyglucose-PET (FDG-PET) and fMRI (rs-fMRI) in patients with disorders of consciousness.

Registry
clinicaltrials.gov
Start Date
January 1, 2018
End Date
January 1, 2021
Last Updated
3 years ago
Study Type
Observational
Sex
All

Investigators

Sponsor
Hangzhou Normal University
Responsible Party
Principal Investigator
Principal Investigator

Jing Wang

Dr.

Hangzhou Normal University

Eligibility Criteria

Inclusion Criteria

  • DOC patients (acute, subacute or chronic period): Coma, UWS and MCS.

Exclusion Criteria

  • neuromuscular blocking agents or sedative drugs administered within the prior 24 hours;
  • unstable medical condition;
  • mental implant in the brain

Outcomes

Primary Outcomes

fludeoxyglucose (FDG-)PET

Time Frame: Within 7 days

UseFDG-PET to test the metabolism.

resting-state fMRI

Time Frame: Within 7 days

Use resting-state fMRI to test the functional connectivity

Study Sites (1)

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