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临床试验/NCT04164680
NCT04164680已完成不适用

Relationship Between Simultaneously Acquired Resting-state Regional Cerebral Glucose Metabolism and Functional MRI in DOC: a PET/MR Hybrid Scanner Study

Hangzhou Normal University1 个研究点 分布在 1 个国家目标入组 24 人开始时间: 2018年1月1日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
24
试验地点
1
主要终点
fludeoxyglucose (FDG-)PET

研究概览

简要总结

Recently introduced hybrid PET/MR scanners provide the opportunity to measure simultaneously, and in direct spatial correspondence, both metabolic demand and functional activity of the brain, hence capturing complementary information on the brain's physiological state. Here we exploited PET/MR simultaneous imaging to explore the relationship between the metabolic information provided by resting-state fluorodeoxyglucose-PET (FDG-PET) and fMRI (rs-fMRI) in patients with disorders of consciousness.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
16 Years 至 80 Years(Child, Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • DOC patients (acute, subacute or chronic period): Coma, UWS and MCS.

排除标准

  • neuromuscular blocking agents or sedative drugs administered within the prior 24 hours;
  • unstable medical condition;
  • mental implant in the brain

结局指标

主要结局

fludeoxyglucose (FDG-)PET

时间窗: Within 7 days

UseFDG-PET to test the metabolism.

resting-state fMRI

时间窗: Within 7 days

Use resting-state fMRI to test the functional connectivity

次要结局

未报告次要终点

研究者

发起方
Hangzhou Normal University
申办方类型
Other
责任方
Principal Investigator
主要研究者

Jing Wang

Dr.

Hangzhou Normal University

研究点 (1)

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