Relationship Between Simultaneously Acquired Resting-state Regional Cerebral Glucose Metabolism and Functional MRI in DOC: a PET/MR Hybrid Scanner Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 24
- 试验地点
- 1
- 主要终点
- fludeoxyglucose (FDG-)PET
研究概览
简要总结
Recently introduced hybrid PET/MR scanners provide the opportunity to measure simultaneously, and in direct spatial correspondence, both metabolic demand and functional activity of the brain, hence capturing complementary information on the brain's physiological state. Here we exploited PET/MR simultaneous imaging to explore the relationship between the metabolic information provided by resting-state fluorodeoxyglucose-PET (FDG-PET) and fMRI (rs-fMRI) in patients with disorders of consciousness.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 16 Years 至 80 Years(Child, Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •DOC patients (acute, subacute or chronic period): Coma, UWS and MCS.
排除标准
- •neuromuscular blocking agents or sedative drugs administered within the prior 24 hours;
- •unstable medical condition;
- •mental implant in the brain
结局指标
主要结局
fludeoxyglucose (FDG-)PET
时间窗: Within 7 days
UseFDG-PET to test the metabolism.
resting-state fMRI
时间窗: Within 7 days
Use resting-state fMRI to test the functional connectivity
次要结局
未报告次要终点
研究者
Jing Wang
Dr.
Hangzhou Normal University
