NCT03595306
Completed
Not Applicable
Human Gut Microbiota and Prebiotic Response
ConditionsHealthy Gut Microbiota
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Healthy Gut Microbiota
- Sponsor
- Duke University
- Enrollment
- 41
- Locations
- 1
- Primary Endpoint
- change in levels of SCFAs in stool samples
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
This study is designed to examine the shift in gut microbiota and their metabolism after consumption of a dietary supplement (prebiotic) by healthy participants. The investigators will provide participants with a panel of over the counter prebiotics and monitor their gut microbiome response in stool. All prebiotics will be commercially available, over-the-counter food, food additives, or dietary supplements, without any known market-use adverse effects beyond minimal discomfort.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Provide Stool Samples at no risk to yourself
Exclusion Criteria
- •No oral antibiotic treatments within previous 1 month
- •No known allergy to milk products or lactose intolerance
- •no known allergy to wheat or gluten intolerance
- •no history of irritable bowel syndrome
- •no history of inflammatory bowel disease
- •no history of type-2 diabetes
- •no history of chronic kidney disease or reduced kidney function
- •no current intestinal obstructions
- •no current untreated colorectal cancer
- •not currently pregnant or breastfeeding
Outcomes
Primary Outcomes
change in levels of SCFAs in stool samples
Time Frame: Baseline and 6 weeks
Secondary Outcomes
- change in levels of cytokines in stool samples(Baseline and 6 weeks)
Study Sites (1)
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