ACTRN12614001024639
Completed
Phase 2
A randomised controlled study, investigating the epigenetic changes in expression of inflammatory genes through associated blood biomarkers, using curcumin, in older healthy and mild cognitive impairment participants
McCusker Alzheimers Research Foundation0 sites48 target enrollmentSeptember 24, 2014
Overview
- Phase
- Phase 2
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- McCusker Alzheimers Research Foundation
- Enrollment
- 48
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Arm 1: Healthy Volunteers
- •1\. Age 65\-90 years, with general good health.
- •2\. No significant history of cerebral vascular disease, such as
- •a stroke, within the last 5 years.
- •3\. Living in independent living units, or similar accommodation
- •4\. English speaker, with adequate vision and hearing to enable testing
- •5\. Normal general cognitive function, as determined by a Montreal Cognitive Assessment (MoCA) score, greater than or equal to 26\.
- •6\. No change in ADLs as determined by a clinical interview, and confirmed by an informant using the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE)
- •Arm 2: Mild Cognitive Impairment Volunteers
- •1\-4, as listed above
Exclusion Criteria
- •1\. Diagnosis of dementia based on the revised NIA/AA criteria
- •2\. MoCA score of less than or equal to 17
- •3\. Prior history of stroke within the last 5 years
- •4\. Significant psychiatric disorder, including schizophrenia or
- •bipolar disorder
- •5\. History of alcohol or drug abuse / dependence within 2
- •years of screening
- •6\. Uncontrolled, clinical or subclinical depression as evidenced
- •by a score of greater or equal to 4 on the Geriatric
- •Depression scale.
Outcomes
Primary Outcomes
Not specified
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