A randomised controlled trial of vitamin C and E supplementation to prevent pre-eclampsia in women at risk

King's College London (UK)0 个研究点目标入组 2,400 人开始时间: 2003年11月17日最近更新: 2016年10月17日

适应症

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•Women with identified additional risk factors for pre-eclampsia in ten geographical areas, and 22 hospitals through England:
•1. Pregnant women between 14 and 22 weeks' gestation
•2. A history of pre-eclampsia (requiring delivery less than 37 weeks) in preceding pregnancy, eclampsia or Haemolysis, Elevated Liver enzyme levels and Low Platelet count (HELLP) syndrome (at any time)
•3. Women with essential hypertension, diabetes (requiring treatment), Systemic Lupus Erythrematosus (SLE)/Anti-Phospholipid antibody Syndrome (APS) with renal imvolvement
•4. In the current pregnancy: abnormal uterine artery Dopplers (18 to 22 weeks), multiple pregnancy, diastolic Blood Pressure (BP) more than 90 mmHg (before 20 weeks)
•5. Primparous women with Body Mass Index (BMI) more than 30

•1. Inability/unwillingness to give informed consent
•2. Women taking warfarin (due to the theoretical potentiation of warfarin by Vitamin E)

发起方

King's College London (UK)