Experimental and Pilot Clinical Evaluation of safety and efficacy of Nano Kanchanara (Bauhinia variegata Linn) Twak Extract in Hypothyroidism

Hypothyroidism is a hypo-metabolic clinical stateresulting from inadequate production of thyroid hormone for prolonged period orrarely, from resistance of the peripheral tissue to the effect of thyroidhormones. Primary hypothyroidism is a dysfunction in the thyroid gland and,it can be sub-clinical or overt. Due to easily stimuli like stress and anxiety, the global incidence of hypothyroidism is increasing. Kanchanara reduce the swelling of neck, increased serum thyroid hormoneconcentration, decreased cholesterol and improve thyroid histology. Kanchanara stem bark has been investigated and reported tohave anti-tumor property.  Kanchanara extract, as standardized extracts, provide unlimited opportunitiesfor uncovering new drug because of the innumerable availability of chemical composition. Prevalence rate of Hypothyroidism in developed countries is 4.6% . Where as inIndia it is 10.95%. Incidence rate of hypothyroidism is more infemales (15.86%) than males (5.02%).  Lacunas in current management. HRT is the single available treatment& Long-term metabolic complications of HRT. Increaseddosage and continuous medication make the patient drug dependent tillthe end of the life. So therefore need to find new drug which willprevents further lacunas hence extraction of  Kanchanar Twak willhelp to concentrate the chemical constituent in a soluble form and by using Nanotechnology we will able to level up herbs bioavailability,effectiveness and also able to reintroduce other component that were discardeddue to poor characteristics.