Detection of (sub) clinical toxicity in irradiated vs. non-irradiated surgically treated esophageal cancer patients: a pilot study.

Completed

Conditions: cardiopulmonary dysfunction
toxicity heart/lung
10082206
10017990

Registration Number: NL-OMON44510

Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 40

Inclusion Criteria

- Treated for EC with a curative resection between 2000 and 2012
- Age >= 18 years
- Written informed consent
- No signs of tumor recurrence or new other malignancies.

Exclusion Criteria

- Thoracic radiotherapy for indications other than EC.
- Contra indication for cardiac MRI, pacemaker, cochlear implants, metal not compliable with MRI.

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>As this is an exploratory pilot study to determine the most suitable diagnostic<br /><br>tests for future studies, there will be several endpoints related to<br /><br>(sub)clinical cardiopulmonary dysfunction.<br /><br>Signs of myocardial ischemia, systolic or diastolic dysfunction, rhythm and<br /><br>valve disorders, pericardial effusion and fibrosis, myocardial fibrosis, focal<br /><br>wall motion disorders and coronary calcifications will be analyzed. The<br /><br>cardiopulmonary (dys)function in EC survivors treated with neo-CRT followed by<br /><br>surgical resection will be compared to cardiopulmonary (dys)function in EC<br /><br>survivors treated with surgical resection alone.</p><br>

Secondary Outcome Measures