Randomised Controlled double blinded Human Clinical Trial on the Effectiveness of CS Sinonasal Rinse vs CS Sinonasal Rinse and ABX, vs topical ABX vs oral ABX and saline Sinonasal Rinse (standard of care) in the Management of Patients with CRS

Central Adelaide Local Health Network0 个研究点目标入组 44 人开始时间: 2023年1月9日最近更新: 2024年8月5日

适应症

试验速览

暂无简介。

•Participants must have had at least two of the following symptoms of chronic rhinosinusitis (nasal discharge, postnasal drip, nasal obstruction, facial pain and pressure or lack of sense of smell) that has been previously persistent for greater than 3 months.
•Participants must have had endoscopic sinus surgery (ESS) and be able to start the trial anytime from two weeks post-operative.
•Participants must show evidence of chronic sinusitis by direct endoscopic examination. Participants must show evidence of infectious exacerbation by direct endoscopic examination and have a positive culture diagnosis with pathogens that show sensitivity to mupirocin and/or tobramycin and/or oral antibiotic.
•Participants must have the ability to administer daily sinus rinses for the duration of the treatment period.
•Participants must be aged 18 years or over.
•Participants must be able to give written informed consent.
•Participants must have the ability and willingness to attend several visits to the outpatients.
•Participants must have the willingness and ability to comply with the requirements of the protocol as determined by the Investigator.

•Participants who are unlikely to comply with the study protocol or, in the opinion of the investigator, would not be a suitable candidate for participation in the study. Pregnant and breastfeeding women will also be excluded.
•Participants who are actively taking oral steroids or antibiotics will be excluded from the study.

发起方

Central Adelaide Local Health Network