Xenograft with or Without Erythropoietin in Immediate Dental Implant

Not Applicable

Not yet recruiting

• Conditions: Hopeless Teeth
• Interventions: Combination Product: Erythropoietin (EPO) with xenograft; Other: Xenograft alone

• Registration Number: NCT06601400
• Lead Sponsor: Cairo University

Brief Summary

The aim of this study is to evaluate changes in buccal bone thickness after immediate implant placement with xenograft mixed with erythropoietin in the anterior maxilla with a thin buccal bone

Detailed Description

PICO:

Population: Patients with non-restorable tooth in anterior maxilla with thin buccal bone (less than 1mm) Intervention: Immediate implant placement with Xenograft mixed with Erythropoietin.

Control: Immediate implant placement with Xenograft alone.

Study Timeline

• Status Verified: 2024-09
• Study First Submitted: 2024-09-11
• Study Start: 2024-09-14
• Study First Submitted QC: 2024-09-14
• Last Update Submitted: 2024-09-14
• Study First Posted: 2024-09-19
• Last Update Posted: 2024-09-19
• Primary Completion: 2025-10
• Study Completion: 2026-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Group A (Test)	Erythropoietin (EPO) with xenograft	Immediate implant placement with Xenograft mixed with Erythropoietin
Group B (Control)	Xenograft alone	Immediate implant placement with Xenograft alone

Primary Outcome Measures

Name	Time	Method
Buccal bone thickness.	1 year follow up period	by Cone Beam Computed Tomography (CBCT) in mm

Secondary Outcome Measures

Name	Time	Method
Crestal bone loss	1 year follow up period	will be measured by Cone Beam Computed Tomography (CBCT) in mm
Soft tissue thickness.	1 year follow up period	will be measured by Endodontic spreader with rubber stopper in mm
The pink esthetic score (PES)	1 year follow up period	by taking photographs
Success and survival criteria	1 year follow up period	the absence of mobility, the absence of acute or chronic peri-implant infection, the absence of radiolucency around the implant, without pocket probing depth (PPD) ≧ 5 mm, and without vertical bone loss ≧ 1.5 mm in the first year. The cases will be defined as failure if it can\'t reach any one of the success criteria
Bleeding on probing (BOP)	1 year follow up period	According to presence (yes) or absence (No) of bleeding on probing
Pain score	1, 3, and 7 days	by using Visual analogue scale from (0-10)
Full-mouth plaque score	1 year follow up period	According to presence (yes) or absence(No) of plaque

Trial Locations

Locations (1)

Faculty of dentistry, Cairo university; 🇪🇬 Giza, Egypt