Effect of pilocarpine 2% eye drops on treatment resistant oral erosions of pemphigus.
Phase 3
Completed
- Conditions
- Health Condition 1: null- recalcitrant oral ulcers of pemphigus vulgaris
- Registration Number
- CTRI/2017/11/010445
- Lead Sponsor
- IADV
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
2.Refractory oral PV, arbitrarily defined for present study as less than 75% reduction in ABSIS score after being treated with optimum systemic and topical treatment for 6 months; with lesions at sites accessible to topical pilocarpine application including retro-molar trigone, buccal mucosa, gingiva and palate.
Twenty PV patients satisfying above-mentioned inclusion criteria will be recruited for this pilot study
Exclusion Criteria
Not provided
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Primary aim of present study is to assess the efficacy and safety of topical pilocarpine 2% eye-drops (in terms of reduction in the size of erosions) in treatment of refractory/ persistent oral lesions of pemphigus vulgaris (PV) situated on buccal mucosa, retro-molar trigone, gingiva and palate. <br/ ><br> <br/ ><br>Also, measurement of anti desmoglein 1 and 3 antibodies will be done in both saliva and serum, at the time of inclusion in study and after completion of treatment.Timepoint: 6 months
- Secondary Outcome Measures
Name Time Method Secondary aim is to assess the effect of pilocarpine application on subjective improvement and quality of life as experienced by the patient (using VAS and OHIP-14 scoring).Timepoint: 6 months