The effect of drop pilocarpine on oral lesions in pemphigus vulgaris

Phase 2

• Conditions: L10.0; pemphigus vulgaris oral lesions.; Pemphigus vulgaris

• Registration Number: IRCT20221002056070N1
• Lead Sponsor: Tehran University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 January 2024

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 42

Inclusion Criteria

Clinical and histopathological confirmation of pemphigus vulgaris
Patients with resistant oral ulcers that have not been treated with systemic drugs or have relapsed after treatment
Age between 20-70
Accessible mouth lesions(retromolar trigone)

Exclusion Criteria

oral lesions more than 2-3

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Size of oral lesions. Timepoint: Baseline visit, week 4 and week 8. Method of measurement: Measuring the size of lesions in photos by software, evaluation of patient satisfaction, oral lesion status and disease severity using VAS, ODSS and PDAI questionnaires.

Secondary Outcome Measures

Name	Time	Method
Pemphigus disease area index (PDAI). Timepoint: Baseline visit and week 8. Method of measurement: Pemphigus disease area index questionnaire (PDAI).