Commonalities in visual perception between children at familial risk for synaesthesia and in children with autism spectrum disorder

Recruiting

Conditions: autisme spectrum stoornis en synesthesie (veranderde waarneming)
ASD
synaesthesia
autism
mixing of the senses

Registration Number: NL-OMON47046

Lead Sponsor: Radboud Universiteit Nijmegen

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 84

Inclusion Criteria

Autism group: ADOS or ADI-verified ASD diagnosis according to DSM-5, age 4-5 years old, Performance IQ>85
Healthy controls: 4 or 5 years old, starting Group 2 of primary school in same calendar year
Healthy controls at familial risk for synaesthesia: as control group but at least one parent has a form of synaesthesia as verified by a consistency test.

Exclusion Criteria

visual impairments, seizure disorders, history of serious head injury, claustrophobia, psychotropic medication, genetic syndromes that are known to cause autism spectrum disorder (e.g. Fragile X, Angelman syndrome)

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main dependent variables are:<br /><br>* Time locked voltage changes (*V) at different electrode sites (EEG), i.e. the<br /><br>ratio between the N1/ P1 components at occipital sites for achromatic visual<br /><br>stimuli</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Time locked voltage changes (V) at different electrode sites (EEG) for<br /><br>chromatic visual stimuli<br /><br>- Power changes (V2) at different electrode sites (EEG)<br /><br>- Percentage correct hits in a prospective memory experiment (distractor task)<br /><br>- Reading proficiency scores on a passive and an active reading task (% correct)<br /><br>- Synaesthesia scores (% of consistent colour associations across sessions).<br /><br>- Control measurements: Social Responsiveness Scale, Sensory Profile, IQ tests.</p><br>