ACTRN12612000535875已完成1 期
In paediatric patients with high risk brain tumours, is it safe and feasible to infuse autologous Peripheral Blood Stem Cells transduced with a mutant MGMT Gene?
The Sydney Children's Hospital Network0 个研究点目标入组 12 人开始时间: 2012年5月21日最近更新:
适应症
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 发起方
- 入组人数
- 12
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Non-randomised trial
- 主要目的
- Treatment
入排标准
- 年龄范围
- 1 Years 至 21 Years（—）
- 性别
- All
入选标准
- •1. Patient diagnosed with one of the following:
- •a) High grade glioma which has progessed or recurred following standard therapy
- •b) Medulloblastoma which has recurred following conventional therapy
- •c) Ependymoma which has recurred following maximal safe surgical resection and radiotherapy, and where maximal safe re-section and re-irradiation has been undertaken or considered not appropriate
- •d) Atypical teratoid/rhabdoid tumour which has recurred
- •e) Low grade glioma which has recurred
- •f) Brainstem glioma of diffuse pontine type
- •2. Life expectancy greater than or equal to 8 weeks
- •3. No severe uncontrolled infection
- •4. Performance status :
- •a) Karnofsky score > or equal to 50% (patient over 10 years old) OR
- •b) Lansky score > or equal to 50% (patient under/equal 10 years old)
- •5. Patient has adequate bone marrow function
- •6. Signed Informed Consent
排除标准
- •1. Uncontrolled infection
- •2. Malignant infiltration of the bone marrow or any other site outside the central nervous system
研究者
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