Comparative study between intravenous versus epidural lignocaine in ischemia reperfusion injury during total knee arthroplasty

Not Applicable

• Conditions: Injury, Occupational Diseases, Poisoning; Surgery; Total knee replacement

• Registration Number: PACTR201411000929541
• Lead Sponsor: Department of anesthesia and surgical intensive care

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2014-11-06
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

elective unilateral total knee arthroplasty due to osteoarithitis

Exclusion Criteria

-patients using alpha or beta blockers
-patients with allergy to other amide local anesthetics
- impaired liver functions
- chronic use of corticosteroids or non steroidal anti-inflammatory diseases
- patients with chronic inflammatory diseases
- heart block
- antibiotic treatment or inter-current infections
-pagets disease
-revision arthroplasty 10- cancer 11- vascular disorders

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Total leukocyte count;Intracellular hydrogen peroxide;Soluble intercellular adhesion molecule;Von willbrand factor

Secondary Outcome Measures

Name	Time	Method
Assessment of pain