The Comparison of Nutritional Outcomes between Different Techniques of Intradialytic Amino Acid Infusion In Hemodialysis Patient: A Randomized Controlled Trial

Phase 1

Completed

• Conditions: Continuous intradialytic amino acid infusion is higher change of albumin level than loading dose of amino acid at 3 months; Intradialytic parenteral nutrition; Amino acid supplementation; Intravenous infusion; End-stage kidney disease; Hemodialysis

• Registration Number: TCTR20230401003
• Lead Sponsor: Faculty of Medicine, Chulalongkorn University

Brief Summary

The change of serum albumin level between both techniques were not significantly different at the end of study. Despite comparable energy and protein intake, serum albumin levels were significantly increased in continuous group whereas it was still unchanged in the loading group. The average total AA losses in dialysate were not significantly different. Both plasma essential and non-essential AA levels between groups were also similar. Muscle mass, strength, and gait speed did not differ.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-04-01
• Study Completion: 2024-03-31
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 48

Inclusion Criteria

Adult patients (greater than or equal to 18 years old)
Hemodialysis (greater than or equal to 3 months)
Serum Alb 3.5 to 3.9 g/dL
7-points SGA A or Malnutrition inflammation score A or B

Exclusion Criteria

Allergy to Amino acid supplement
Pregnancy or breastfeeding
Metastatic cancer
Ongoing infection
On anti inflammatory drugs
Cirrhosis
HIV infection

Study & Design

• Study Type: Interventional
• Study Design: Not specified