The Weight-Wise Weight Loss Translation Study

Not Applicable

Completed

• Conditions: Overweight; Obesity; Cardiovascular Disease
• Interventions: Behavioral: Special Intervention; Behavioral: Delayed Intervention

• Registration Number: NCT01141348
• Lead Sponsor: University of North Carolina, Chapel Hill

Brief Summary

The overall goal of the translational research is to evaluate the processes and outcomes of implementing, in a range of public health agencies, an intense, evidence-based behavioral weight loss intervention with demonstrated effectiveness among midlife low-income women. The intervention was originally studied in a single coordinated community health care center/church setting and delivered by research staff. The investigators will evaluate the intervention's translation and test its effectiveness as implemented by existing staff in six public health agencies supported by local community resources.

Detailed Description

Low-income women in the US have the highest rates of overweight and obesity, putting them at increased risk for diabetes, heart disease, and other chronic illnesses. Because mean body mass index gradually increases during adult life and peaks at 50-59 years of age, low income women between 40-64 years are a group deserving of special attention. While there is sufficient evidence that some behavioral weight management interventions are effective in producing clinically meaningful levels of weight loss with reductions in cardiovascular risk factors and delayed onset of diabetes, there is a research gap in translating these efficacious interventions to real life settings and diverse population groups. Research that seeks to translate effective behavioral weight management interventions from resource-intensive efficacy trials to long-term adoption and implementation by public health settings serving a diverse low-income population is timely and of great public health significance. This translational research can provide important information to decision-makers about evidence-based intervention delivery, resource allocation, and workforce preparation.

The overall goal of the proposed research is to evaluate the processes and outcomes of translating from research to practice an intense, evidence-based behavioral weight loss intervention with demonstrated effectiveness among midlife low-income women. Originally studied in a single coordinated community health care center/church setting and delivered by research staff (Weight-Wise Pilot Study), we will evaluate the translation of and test the effectiveness of this intervention as implemented by existing staff in a range of county health departments supported by local community resources.

To evaluate the translation process, we will use the RE-AIM framework, diffusion of innovation theory, and systematic models of adaptation to assess: 1) factors related to reach; contextual or setting-specific factors necessary for successful adoption and implementation; 2) effectiveness of facilitator training and stakeholder collaborations; 3) adaptation and fidelity during implementation; and 4) costs associated with the implementation and outcomes. To test the intervention's effectiveness, we will enroll 240 overweight or obese low-income women, 40-64 years of age, at 6 representative public health agencies. Participants will be randomized to receive a 16-week behavioral weight loss intervention (special intervention group) or usual care (wait listed control group). The primary study outcome at 5 month follow-up is weight change; secondary outcomes include change in blood pressure, dietary intake, physical activity, and quality of life measures.

Study Timeline

• Study Start: 2009-01
• Primary Completion: 2010-01
• Study Completion: 2010-01
• Study First Submitted: 2010-05-06
• Status Verified: 2010-06
• Study First Submitted QC: 2010-06-09
• Last Update Submitted: 2010-06-09
• Study First Posted: 2010-06-10
• Last Update Posted: 2010-06-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 189

Inclusion Criteria

1. BMI between 27.5 and 45
2. willing to lose 5% or more of initial body weight and follow recommendations for healthy dietary and PA patterns
3. English-speaking
4. able and willing to give informed consent
5. household income less than or equal to 250% of federal poverty guidelines.

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Exclusion Criteria

1. medical or physical limitations to engaging in moderate level physical activity
2. medical or other contraindications to weight loss
3. history of gastric bypass surgery or scheduled surgery for this purpose
4. weight loss of > 20 lbs in the last 3 months
5. current use of medication for weight loss
6. treatment of psychosis
7. diagnosis of Type 1 diabetes.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Special Intervention	Special Intervention	-
Delayed Intervention	Delayed Intervention	-

Primary Outcome Measures

Name	Time	Method
Weight Change difference between baseline and 4 month follow-up	Baseline and 4 month follow-up

Secondary Outcome Measures

Name	Time	Method
Change in blood pressure, dietary intake, physical activity, and quality of life between baseline and 4 month follow-up	Baseline and 4 month follow-up

Trial Locations

Locations (6)

Albemarle Regional Health Services; 🇺🇸 Elizabeth City, North Carolina, United States

Lincoln County Health Department; 🇺🇸 Lincolnton, North Carolina, United States

Davidson County Health Department; 🇺🇸 Lexington, North Carolina, United States

Nash County Health Department; 🇺🇸 Nashville, North Carolina, United States

Warren County Health Department; 🇺🇸 Warrenton, North Carolina, United States

Forsyth County Health Department; 🇺🇸 Winston-Salem, North Carolina, United States