The Effect of Liposome Vitamin C on the Absorption
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- TCI Co., Ltd.
- Enrollment
- 11
- Locations
- 2
- Primary Endpoint
- vitamin c detection
Study Overview
Brief Summary
To evaluate the difference between vitamin C in the form of oral liposomes and general vitamin C in a fixed period of time in plasma and urine.
Detailed Description
we recruited 11 healthy subjects and adopted a cross-over test. the subjects need to take 3 tests during trail. After each test was completed, a washout period of 14 days was required before the next test start. The subjects were informed to consume one sachet vitamin C without liposome, liposomal process A vitamin C, or liposomal process B vitamin C (Double Nutri™) every test, and vitamin C concentration was measured at baseline (0 hours), 0.5, 1, 2, 3, 4, and 8 hours after taking test sample.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Treatment
- Masking
- Double (Participant, Investigator)
Eligibility Criteria
- Ages
- 20 Years to 60 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Adults between 20-60 years old,
- •No heart, liver, kidney, endocrine and major organic diseases
Exclusion Criteria
- •Renal insufficiency and dialysis
- •Underweight (BMI≦17) or obese (BMI≧27),
- •Take chronic disease drugs,
- •Blood pressure systolic blood pressure ≧130 mmHg or diastolic blood pressure ≧85 mmHg,
- •Too high fasting blood glucose ≧ 100 mg/dL,
- •Triglyceride ≧ 150 mg/dL,Total cholesterol ≧ 200 mg/dL,
- •Have a history of vitamin C allergy,
- •People with mental illness,
- •Pregnant or breastfeeding women,
- •Kidney stones,
- •Long-term vitamin C supplements (at least 200 mg per day for more than one month)
Outcomes
Primary Outcomes
vitamin c detection
Time Frame: at 8 hours after taking test sample
vitamin c was assessed by Ascorbic Acid Colorimetric Assay Kit II
The change of Triglyceride
Time Frame: at 8 hours after taking test sample
Venous blood was sampled to measure concentrations of Triglyceride
The change of aspartate aminotransferase
Time Frame: at 8 hours after taking test sample
Venous blood was sampled to measure concentrations of aspartate aminotransferase
The change of body mass index (BMI)
Time Frame: Time 0, 0.5, 1, 2, 3, 4, and 8 hours after taking test sample
BMI is a measurement of a person's leanness or corpulence based on their height and weight, and is intended to quantify tissue mass.The body mass index (BMI, kg/m\^2) and body mass (kg) were assessed by InBody770.
The change of alanine aminotransferase
Time Frame: at 8 hours after taking test sample
Venous blood was sampled to measure concentrations of alanine aminotransferase
The change of creatine
Time Frame: at 8 hours after taking test sample
Venous blood was sampled to measure concentrations of creatine
Secondary Outcomes
No secondary outcomes reported