Bioavailability of Orally Ingested Vitamin C

Not Applicable

Withdrawn

• Conditions: Healthy
• Interventions: Dietary Supplement: Phosphatidylcholine-lipid encapsulated vitamin C; Dietary Supplement: Crystalline vitamin C

• Registration Number: NCT05183880
• Lead Sponsor: University of Exeter

Brief Summary

The purpose of this study is to determine if crystalline vitamin C supplementation can acutely increase skeletal muscle vitamin C concentrations and if this can be potentiated by administering vitamin C using Phosphycell™ Technology - a phosphatidylcholine-lipid encapsulation technology.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-11-26
• Study First Submitted: 2021-12-21
• Study First Submitted QC: 2021-12-21
• Study First Posted: 2022-01-11
• Primary Completion: 2022-11-26
• Study Completion: 2023-11-26
• Status Verified: 2024-05
• Last Update Submitted: 2024-05-13
• Last Update Posted: 2024-05-16

Recruitment & Eligibility

• Status: WITHDRAWN
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• Body mass index (BMI) 18.5 - 30 kg/m2
• Age 18 - 40
• Non-smoker

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Exclusion Criteria

• Body mass index (BMI) < 18.5 or > 30 kg/m2
• Age < 18 or > 40
• Smoking
• Cardiovascular disease
• Hypertension (≥ 140/90 mmHg)
• Metabolic disease
• Medications known to affect vitamin C metabolism
• A known vitamin C deficiency
• Less than 2 hours per week of physical activity or following a structured exercise training program.
• Routine use of vitamin supplements

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Phosphatidylcholine-lipid encapsulated vitamin C supplementation	Phosphatidylcholine-lipid encapsulated vitamin C	1000 mg of vitamin C ingested in phosphatidylcholine-lipid encapsulated form
Crystalline vitamin C supplementation	Crystalline vitamin C	1000 mg of vitamin C ingested in crystalline form

Primary Outcome Measures

Name	Time	Method
Skeletal muscle vitamin C concentrations	12 hours after vitamin C ingestion	Skeletal muscle vitamin C concentrations 12 hours after vitamin C ingestion will be measured using HPLC and compared to baseline and 6 hours after vitamin C ingestion

Secondary Outcome Measures

Name	Time	Method
White blood cell vitamin C concentrations	24 hours after vitamin C ingestion	White blood cell vitamin C concentrations will be measured 24 hours after vitamin C ingestion using HPLC and compared to baseline and 3 hours post vitamin C ingestion
Cardiovascular function	24 hours after vitamin C ingestion	Cardiovascular function will be measuring using a finger plethysmograph during the 24 hour post vitamin C ingestion period
Blood plasma vitamin C concentrations	24 hours after vitamin C ingestion	Blood plasma vitamin C concentrations will be measured using HPLC during the 24 hour post vitamin C ingestion period

Trial Locations

Locations (1)

Sport and Health Sciences; 🇬🇧 Exeter, Devon, United Kingdom