NCT05183880WithdrawnNot Applicable
Investigating the Oral Bioavailability of Vitamin C Administered Using Phosphycell™ Technology - a Phosphatidylcholine-lipid Encapsulation Technology.
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Withdrawn
- Sponsor
- University of Exeter
- Locations
- 2
- Primary Endpoint
- Skeletal muscle vitamin C concentrations
Study Overview
Brief Summary
The purpose of this study is to determine if crystalline vitamin C supplementation can acutely increase skeletal muscle vitamin C concentrations and if this can be potentiated by administering vitamin C using Phosphycell™ Technology - a phosphatidylcholine-lipid encapsulation technology.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Basic Science
- Masking
- Double (Participant, Investigator)
Eligibility Criteria
- Ages
- 18 Years to 40 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Body mass index (BMI) 18.5 - 30 kg/m2
- •Age 18 - 40
- •Non-smoker
Exclusion Criteria
- •Body mass index (BMI) < 18.5 or > 30 kg/m2
- •Age < 18 or > 40
- •Cardiovascular disease
- •Hypertension (≥ 140/90 mmHg)
- •Metabolic disease
- •Medications known to affect vitamin C metabolism
- •A known vitamin C deficiency
- •Less than 2 hours per week of physical activity or following a structured exercise training program.
- •Routine use of vitamin supplements
Outcomes
Primary Outcomes
Skeletal muscle vitamin C concentrations
Time Frame: 12 hours after vitamin C ingestion
Skeletal muscle vitamin C concentrations 12 hours after vitamin C ingestion will be measured using HPLC and compared to baseline and 6 hours after vitamin C ingestion
Secondary Outcomes
- White blood cell vitamin C concentrations(24 hours after vitamin C ingestion)
- Cardiovascular function(24 hours after vitamin C ingestion)
- Blood plasma vitamin C concentrations(24 hours after vitamin C ingestion)
Investigators
Study Sites (2)
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