The Efficacy of High Dose Vitamin C in the Critically Ill Patient Population
试验速览
- 阶段
- 2 期
- 状态
- 终止
- 入组人数
- 11
- 试验地点
- 1
- 主要终点
- Efficacy of High Dose Vitamin C Therapy in Shock Patients
研究概览
简要总结
The purpose of this study is to determine the effectiveness of high doses of Vitamin C in critically ill patients.
详细描述
It has been shown that the stress that occurs during trauma, infection and/or shock depletes many of the body's resources such as Vitamin C (ascorbic acid) which may contribute to further complications. The purpose of this study is to determine the effectiveness of high doses of Vitamin C in critically ill patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Activation of the Mass Transfusion Protocol following surgery or trauma.
- •Diagnosis of septic shock. Septic shock will be defined as sepsis induced hypotension (i.e. systolic blood pressure <90mmHg or drop of systolic blood pressure >40mmHg in the presence of infection) that does not respond to a 2 liter fluid bolus.
排除标准
- •Age less than 18 years.
- •Pregnant women.
- •Creatinine of greater than 2.2 g/dl at time of enrollment, history of chronic kidney or end stage renal disease, rise in creatinine > 1 g/dl within 24 hours prior to enrollment.
- •Brain death diagnosed within 4 hours of presentation to the trauma bay or intensive care unit
- •Patients with history of hemolytic blood disease, e.g. glucose-6-phosphate dehydrogenase deficiency, Sickle Cell Disease and Thalassemia.
- •Patients in isolated cardiogenic shock.
- •History of liver cirrhosis
- •Transplant patients (liver, kidney, heart)
研究组 & 干预措施
Ascorbic Acid
Ascorbic Acid
干预措施: Ascorbic Acid (Drug)
Ringers Lactate or Normal Saline
Ringers Lactate or Normal Saline
干预措施: Ringers Lactate or Normal Saline (Other)
结局指标
主要结局
Efficacy of High Dose Vitamin C Therapy in Shock Patients
时间窗: 30 days
Given the grim prognosis of septic and hypovolemic shock, we aim to study the efficacy on an alternative treatment modality by implementing high dose vitamin C therapy in our patient population. Through previous investigations, especially research in the burn patient population, we expect that high dose vitamin C therapy will be beneficial to patients with hypovolemic or septic shock.
次要结局
未报告次要终点