NCT04682574已完成不适用
Effects of Mega Dose Vitamin C in Critically Ill COVID-19 Patients: A Randomized Control Trial
University of Lahore1 个研究点 分布在 1 个国家目标入组 278 人开始时间: 2020年11月2日最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 278
- 试验地点
- 1
- 主要终点
- Partial pressure of Oxygen in arterial blood to fraction of inspired Oxygen (P/F ratio)
研究概览
简要总结
Vitamin C (ascorbic acid) is a water-soluble vitamin having anti-inflammatory, immunomodulatory, anti-oxidative, antithrombotic and antiviral properties. Considering these effects vitamin C should have beneficial impact in patients suffering from sepsis and acute respiratory distress syndrome (ARDS). The current study is designed to assess the beneficial effects of Vitamin C in COVID-19 infected patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •critically ill patients admitted in ICU
排除标准
- •allergic to Vitamin C didnt given the consent
研究组 & 干预措施
vitamin C
Active Comparator
The dose would be 30 grams a day (10 grams TDS) for 3 days with standard treatment
干预措施: Vitamin C (Drug)
结局指标
主要结局
Partial pressure of Oxygen in arterial blood to fraction of inspired Oxygen (P/F ratio)
时间窗: 1 and 4th day
Survival analysis
时间窗: 28 days follow up
次要结局
- Length of Hospital stay(Admission to discharge)
- Need for intubation(28 days)
- Inflammatory markers(before the start of treatment (day 1) and on day 4)
- APACHE II score(before the start of treatment (day 1) and on day 4)
研究者
Muhammad Mansoor Hafeez
Doctor
University of Lahore
研究点 (1)
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